A Longevity Expert’s Guide to the Best NAD+ Supplements

The most effective NAD+ supplements have quickly established themselves as wellness staples, offering benefits ranging from increased energy production and skin health improvements to potential lifespan extension. In a society captivated by revolutionary anti-aging advances, nicotinamide adenine dinucleotide (NAD+), often referred to as the “fountain of youth” within biochemical discussions, is experiencing a significant surge in popularity. Regardless of its delivery method, NAD+ boosters are created to enhance NAD levels in the body and tackle an array of age-related issues: consider brain fog, sagging skin, muscle loss, and the gradual decline of metabolic health.

“NAD+ is crucial for nearly every key cellular function,” states board-certified internist and longevity authority Dr. Amanda Kahn in an interview with Vogue. “It assists your cells in producing ATP (energy), guards against oxidative stress, aids in DNA repair, stimulates collagen and elastin production for supple skin, keeps brain and immune cells functioning at their best, and supports microvascular health for efficient nutrient delivery throughout tissues,” she explains. “Importantly, NAD+ activates sirtuins, proteins vital for managing inflammation and repair, both essential to longevity.” In essence, it’s the ultimate supplement for promoting healthy aging.

Vogue’s Top Picks for NAD+ Supplements

However, there’s a catch: NAD+ molecules are too large to directly penetrate cell membranes, prompting a discussion about their direct impact. This is where supplements come in—more specifically, NAD+ boosters. “Supplements labeled as NAD+ boosters typically include NR (nicotinamide riboside), NMN (nicotinamide mononucleotide), or another precursor to NAD+,” explains longevity expert and founder of Timebeam Beauty, Dr. Lamees Hamdan to Vogue. “The body uses these precursors to eventually convert to NAD+.”

With the science rapidly progressing and aging being an ongoing concern, we sought input from leading experts on the latest advancements, key ingredients to consider, and how to select the best NAD+ supplements for skin radiance, sustained energy, and cellular repair.

In This Article

• What is NAD+?
• How does NAD+ work in the body?
• Benefits of NAD+ Supplements
• Are NAD+ supplements good for you?
• What to Look for in NAD+ Supplements
• Are there any side effects to taking NAD+ supplements?
• How much NAD+ should you take each day?
• How We Tested
• Meet the Experts

• Why We Love It: Dr. Kahn endorses Tru Niagen for its efficiency in oral NAD+ supplementation due to its “robust scientific backing, third-party testing, and commitment to quality.” This supplement features a patented ingredient called Niagen—comprising nicotinamide riboside (NR), a remarkable form of vitamin B3 and a precursor to NAD+. NR is an effective means of raising NAD+ levels since it can pass through the cell membrane directly. Tru Niagen’s proprietary Niagen has been clinically evaluated for its safety and effectiveness in over 35 peer-reviewed studies (which are conveniently listed on its website). It collaborates with prestigious institutions like Mayo Clinic and Harvard, ensuring that 90% of its research is independently conducted—meaning it’s either executed or funded by a third party.
• Type: NR
• Serving Size: 2 capsules
• Doses per Bottle: 30
• Key Ingredients: Nicotinamide riboside chloride, vegetarian capsule shell, vegetable magnesium stearate
• More To Know: Vegetarian, gluten-free, FDA-notified, allergen-free

• Why We Love It: Packed with a unique blend of NMN, vitamin D, resveratrol, and the antioxidant powerhouse hydroxytyrosol, this NAD+ supplement is lauded as one of the finest in its category by longevity experts. Dr. Kahn mentions, “Oral precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are efficiently absorbed, converting to NAD+ within cells.” Promising pre-clinical studies suggest that NMN may positively affect cognitive function. The brand engages numerous well-respected medical and scientific advisors, including the Harvard-, Yale-, and Columbia-trained Dr. Andrew Salzman, MD, who contributed to the development of this formula.
• Type: NMN
• Serving Size: 2 capsules
• Doses per Bottle: 30
• Key Ingredients: Nicotinamide mononucleotide (NMN), olive fruit extract, vitamin D3, vegan cellulose capsule shells
• More to Know: Non-GMO, vegan, soy-free, gluten-free, dairy-free, preservative-free

• Why We Love It: This capsule not only enhances NAD+ synthesis in cells—your skin’s secret to brilliance—but it also brings additional benefits through resveratrol, an antioxidant derived from grapes noted for its scientifically-supported health perks (the foundation of what’s recognized as the “French paradox”). “I prefer NAD+ boosters paired with other compounds as that combination tends to yield the best outcomes,” Dr. Hamdan states. The brilliance of this formula lies in what’s absent—no fillers, artificial preservatives, or additives.
• Type: NR
• Serving Size: 2 capsules
• Doses per Bottle: 30
• Key Ingredients: Nicotinamide riboside, micronized trans-resveratrol, bioperine (black pepper extract)
• More to Know: Non-GMO, third-party tested, GMP certified

• Why We Love It: In the realm of NAD+, it’s crucial to understand that NAD+ doesn’t function alone. Hamdan has formulated this powder with allied compounds like vitamin C, ribose, and rhodiola. “These additions enhance the efficacy and absorption of NAD+,” she notes. Moreover, Hamdan identifies an exceptionally potent and innovative NAD+ enhancer for this formula—a patented blend known as RiaGev-WS, claiming it surpasses both NMN and NR. “It serves as a direct source of NAD+, bolstering not just NAD+ but two additional longevity factors in the cells known as ATP and glutathione while simultaneously lowering cortisol levels,” she continues. “Additionally, it’s easily absorbed—keeping in mind that if you can’t absorb it, you can’t utilize it.” This sprinkle-friendly, rapidly dissolving powder can be placed on the tongue or combined with either hot or cold beverages, making it one of the most convenient methods for obtaining your daily dose of NAD+.
• Type: RiaGev-WS
• Serving Size: 1 packet
• Doses Per Package: 30 sticks
• Key Ingredients: NAD+ booster, hyaluronic acid, electrolytes, vitamin B12, rhodiola
• More to Know: Vegan, gluten-free, sugar-free, third-party tested