Study Shows Link Between Oral Health and Stroke Risk
Research has long shown a connection between oral health and overall well-being, with conditions like dementia and diabetes being linked to poor oral hygiene. A recent study has now revealed that individuals with both gum disease and tooth cavities are at a significantly higher risk of stroke.
Past studies have individually associated gum disease and cavities with a higher risk of stroke, but few have examined the impact of having both conditions simultaneously. Led by a team from the University of South Carolina, this new study focused specifically on individuals with periodontal disease and dental caries.
“We found that people with both cavities and gum disease had almost twice the risk of stroke compared to those with good oral health, even after adjusting for cardiovascular risk factors,” explained Souvik Sen, the chair of the neurology department at the University of South Carolina.
Research Methodology and Findings
The study included 5,986 adults with an average age of 63, who had no prior history of ischemic stroke or coronary heart disease. Over an average of 21 years, their oral health was monitored in relation to major cardiovascular events, including ischemic stroke.

Participants were divided into three groups based on their oral health status: good oral health, gum disease only, and gum disease with cavities. The incidence of stroke events was found to be 4.1% in the good oral health group, 6.9% in the gum disease only group, and 10% in the gum disease and cavities group.
After adjusting for factors like body mass index and smoking status, the researchers concluded that individuals with gum disease had a 44% increased risk of stroke, while those with both gum disease and cavities had an 86% increased risk.
Potential Mechanisms for the Link
While the study only establishes an association, previous research suggests that inflammation and oral bacteria can contribute to cardiovascular issues by spreading to other parts of the body. Oral bacteria have been found in arterial plaques, which can lead to the formation of clots and potentially trigger ischemic strokes.
“Improving oral health may play a crucial role in stroke prevention efforts,” Sen emphasized.
Overall, individuals with both gum disease and cavities had a 36% higher risk of major cardiovascular events, including strokes and fatal heart conditions. Regular dental checkups were also linked to a lower risk of developing gum disease and cavities.
“Taking care of your oral health is not just about your smile—it could also help protect your brain,” Sen added. “Seeking treatment for gum disease or cavities may not only preserve your teeth but also reduce the risk of stroke.”
The findings of this study were published in Neurology Open Access.

