The charming new Fox series “Best Medicine” brings a fresh take on the classic fish-out-of-water trope, following the story of a Boston heart surgeon named Doctor Best who finds himself reluctantly immersed in the quaint charm of a small coastal town in Maine. Played by the talented Josh Charles, known for his role in “The Good Wife,” Doctor Best grapples with a fear of blood after a traumatic incident at work and takes on the role of the town doctor after the passing of his predecessor.
Set against the backdrop of a picturesque Maine town, “Best Medicine” introduces viewers to a host of quirky and lovable characters who help Doctor Best navigate the idiosyncrasies of small-town life. From his no-nonsense aunt Joan, played by Annie Potts, to his bumbling assistant Elaine and his potential love interest Louisa, portrayed by Abigail Spencer, the residents of the town provide both comedic relief and heartfelt moments as Doctor Best adjusts to his new surroundings.
Each episode of “Best Medicine” brings a new local tradition or challenge for Doctor Best to face, from a baked bean dinner to a high-school baseball game against rival teams. As he grapples with the expectations of his new role as a communal therapist rather than just a medical professional, Doctor Best learns valuable lessons about compassion, empathy, and the importance of human connection.
While the show maintains a light-hearted and feel-good tone, it doesn’t shy away from addressing deeper issues such as the decline of small towns. However, the overall focus remains on the heartwarming interactions and relationships that develop between Doctor Best and the townspeople, offering a refreshing escape from the grittier dramas that often dominate television.
Josh Charles delivers a standout performance as the cantankerous yet endearing Doctor Best, bringing depth and humor to the character. His interactions with the colorful cast of characters add a layer of complexity to the show, balancing out the sweetness with a touch of cynicism.
“Best Medicine” is a delightful addition to Fox’s lineup, offering a blend of humor, heart, and small-town charm. Viewers are sure to be drawn in by the quirky characters, picturesque setting, and the unique dynamic between Doctor Best and the residents of the town. Tune in to the premiere on Fox on Jan. 4 at 8 p.m. ET, and follow Doctor Best’s journey as he navigates the highs and lows of small-town life.

