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American Focus > Blog > Tech and Science > Da Vinci’s DNA Is Potentially in The Hands of Scientists : ScienceAlert
Tech and Science

Da Vinci’s DNA Is Potentially in The Hands of Scientists : ScienceAlert

Last updated: January 9, 2026 8:55 am
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Da Vinci’s DNA Is Potentially in The Hands of Scientists : ScienceAlert
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Unlocking the Mysteries of Leonardo da Vinci’s DNA

Researchers from the groundbreaking Leonardo da Vinci DNA Project have made a remarkable discovery that could provide insights into the genetic makeup of the iconic artist and inventor.

According to a preprint publication, scientists believe they have obtained a sample of DNA from Leonardo da Vinci himself, extracted from a suspected chalk drawing known as the Holy Child. While further testing is required to confirm the authenticity of the genetic material, this development marks a significant step in the study of historical DNA.

The innovative technique employed by the research team allows for the extraction of DNA from a variety of sources, including wax seals on ancient letters and the absorbent nature of paper. This approach has enabled the identification of genetic information from orange trees in the Medici gardens and low-quality human DNA, potentially linked to da Vinci or individuals who handled the artwork.

Da Vinci's DNA
The Holy Child red chalk drawing, thought to have been produced by da Vinci. (Creative Commons)

Analysis of the DNA revealed Y chromosome markers consistent with a male individual from the Mediterranean region, particularly central and southern Italy, where da Vinci hails from. Further comparison of genetic signals across da Vinci-associated artifacts suggests a shared lineage that warrants additional investigation.

Da Vinci's DNA Comparison
Comparative genetic research based on swabs taken from various artifacts. (Singh et al., biorXiv, 2026)

The ultimate goal of the Leonardo da Vinci DNA Project is to locate da Vinci’s final resting place and reconstruct his genome. By tracing his bloodline to living descendants and excavating family tombs for genetic information, researchers aim to shed light on the genetic legacy of the Renaissance master.

While challenges remain in confirming DNA matches with da Vinci, the project’s progress signifies a significant breakthrough in ancient DNA research. The techniques developed by the project hold promise for uncovering genetic insights into other historical figures and artifacts.

See also  UK launches £500M package to support diverse, underrepresented investors and founders

Da Vinci's DNA Extraction
Artist Karina Ã…berg swabs a 14th-century da Vinci family letter. (Paola Agazzi/Archivio di Stato di Prato/Italian Ministry of Culture)

As scientists continue their quest to unravel the genetic mysteries of Leonardo da Vinci, the world eagerly anticipates the revelations that may emerge from this groundbreaking endeavor.

TAGGED:DNAHandsPotentiallyScienceAlertScientistsVincis
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