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American Focus > Blog > Sports > Cardinals vs. Red Sox: Odds, Predictions, Betting Tips & Starting lineups
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Cardinals vs. Red Sox: Odds, Predictions, Betting Tips & Starting lineups

Last updated: April 10, 2026 12:15 am
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Cardinals vs. Red Sox: Odds, Predictions, Betting Tips & Starting lineups
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The St. Louis Cardinals will welcome the Boston Red Sox for a three-game series, starting with the first game on Friday. The Cardinals are entering this matchup following a pair of wins against the Washington Nationals.

On the other hand, the Red Sox had a rocky start against the Milwaukee Brewers, losing the series opener on Monday. However, they rebounded with two consecutive victories to win the series, breaking a streak of three series losses.

Both teams come into this series with recent wins, suggesting an intense and competitive matchup is on the horizon.

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MLB: St. Louis Cardinals vs. Boston Red Sox Odds

Moneyline: Boston Red Sox -149 | St. Louis Cardinals +123

Run Line: Boston Red Sox -1.5 (+119) | St. Louis Cardinals +1.5 (-143)

Over/Under: 7.5 runs (Over -112 / Under -108)

Preview: Probable Starting Pitcher and Lineups

St. Louis Cardinals Predicted Starting Pitcher: Dustin May

Cardinals pitcher Dustin May is scheduled to make his third start of the season against the Red Sox on Friday. The 28-year-old has faced challenges recently, allowing 13 earned runs over his past two outings.

St. Louis Cardinals Predicted Lineup:

Masyn Winn SS

JJ Wetherholt 2B

Iván Herrera DH

Alec Burleson 1B

Nolan Gorman 3B

Jordan Walker RF

Nathan Church LF

Pedro Pagés C

Victor Scott II CF

Boston Red Sox Predicted Starting Pitcher: Connelly Early

For the Red Sox, 24-year-old Connelly Early will take the mound for his third start of the season. In his previous game against the San Diego Padres, Early struggled and was removed after four innings.

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Boston Red Sox Predicted Lineup:

Roman Anthony DH

Trevor Story SS

Jarren Duran LF

Willson Contreras 1B

Wilyer Abreu RF

Caleb Durbin 3B

Marcelo Mayer 2B

Carlos Narváez C

Ceddanne Rafaela CF

Despite the Red Sox’s recent success in breaking their losing streak against the Brewers, the Cardinals are anticipated to have the upper hand, especially with the support of their home crowd.

Prediction: Cardinals 5, Red Sox 3

Betting Tips:

Moneyline: St. Louis Cardinals +123

Run Line: St. Louis Cardinals +1.5 (-143)

Runs: Over 7.5 runs (-112)

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Edited by Chaitanya Prakash

Contents
MLB: St. Louis Cardinals vs. Boston Red Sox OddsPreview: Probable Starting Pitcher and LineupsBetting Tips:
TAGGED:BettingCardinalslineupsoddsPredictionsRedSoxStartingTips
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