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American Focus > Blog > Health and Wellness > ASH 2024: Roundup of news from first day of conference
Health and Wellness

ASH 2024: Roundup of news from first day of conference

Last updated: December 7, 2024 7:09 pm
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ASH 2024: Roundup of news from first day of conference
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The ASH 2024 conference brought exciting news in the field of hematology, with advancements in treatments for rare blood disorders such as immune thrombocytopenia (ITP) and sickle cell disease. Let’s dive into the highlights from the conference.

Sanofi presented promising results from a Phase 3 study of their drug rilzabrutinib for ITP, a condition where the body attacks and destroys its own platelets. The oral treatment showed improved platelet response in 65% of participants compared to a placebo, with a durable platelet response seen in 23% of patients. The drug also reduced bleeding episodes and fatigue. If approved, rilzabrutinib could become a new standard treatment for ITP, offering hope to patients who do not respond well to current therapies.

Novo Nordisk’s pill, etavopivat, showed potential in reducing severe pain crises in patients with sickle cell disease. The Phase 2 study demonstrated a 46% reduction in pain crises compared to a placebo, along with improvements in hemoglobin levels and fatigue. The drug belongs to a class that activates an enzyme to improve red blood cell health, offering a new approach to managing the debilitating effects of sickle cell disease.

Beam Therapeutics presented positive results from their CRISPR-based therapy, BEAM-101, for sickle cell disease. All seven patients treated with the therapy showed significant improvements, with increased levels of healthy fetal hemoglobin and decreased levels of sickled hemoglobin in their blood. While one patient experienced a fatal complication related to the treatment regimen, the overall outcomes were promising, showcasing the potential of CRISPR technology in treating genetic blood disorders.

In addition to these treatment advancements, research presented at the conference highlighted the importance of fertility preservation for sickle cell patients undergoing potentially curative therapies. Despite challenges and complications, fertility preservation procedures were deemed safe and viable for patients, provided they have access to the necessary services. With the rise of gene therapies for sickle cell disease, the need for insurance coverage for fertility services is becoming increasingly important to support patients seeking these treatments.

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Overall, the ASH 2024 conference showcased groundbreaking developments in hematology, offering new hope and possibilities for patients with rare blood disorders. Stay tuned for more updates on these exciting advancements in the field of blood diseases.

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