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American Focus > Blog > Health and Wellness > At FDA two top cancer regulators to depart
Health and Wellness

At FDA two top cancer regulators to depart

Last updated: March 30, 2025 3:01 am
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At FDA two top cancer regulators to depart
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Two deputy directors at the Food and Drug Administration (FDA) who oversee the regulation of cancer drugs are reportedly planning to leave the agency, according to sources familiar with the matter. This news sheds light on the challenges faced by the FDA, including layoffs, policy shifts, and uncertainty, which have led to a drain on talent within the organization.

Paul G. Kluetz, who joined the FDA as a medical reviewer in 2016, and Marc R. Theoret, who joined in 2009, have informed their colleagues of their intentions to depart from the FDA. Both individuals are key figures at the FDA’s Oncology Center of Excellence (OCE), which was established in 2017 by Congress to accelerate the development of cancer treatments.

The OCE brings together experts from across the FDA to expedite the review of medical products for oncologic and hematologic malignancies. Additionally, the center spearheads various research and educational initiatives aimed at advancing the development of cancer therapies.

The departure of Kluetz and Theoret underscores the challenges facing the FDA, including ongoing layoffs and organizational changes. These developments are occurring at a time when the agency is set to lay off thousands more employees, further exacerbating the talent drain within the organization.

The FDA plays a crucial role in ensuring the safety and efficacy of cancer drugs and other medical products. The loss of experienced professionals like Kluetz and Theoret could impact the agency’s ability to effectively regulate and evaluate new cancer treatments. It is essential for the FDA to address the issues driving talent attrition and prioritize the retention of skilled staff members to fulfill its regulatory responsibilities effectively.

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As the FDA navigates these challenges, stakeholders in the healthcare industry will be closely monitoring developments at the agency. The successful regulation of cancer drugs is vital for patients, healthcare providers, and pharmaceutical companies alike. It is imperative for the FDA to address the talent drain and organizational challenges to uphold its mission of protecting public health and promoting innovation in the field of oncology.

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