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American Focus > Blog > Tech and Science > Bed Bugs Appear to Have a Genetic Resistance to Pesticides : ScienceAlert
Tech and Science

Bed Bugs Appear to Have a Genetic Resistance to Pesticides : ScienceAlert

Last updated: April 27, 2025 12:45 pm
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Bed Bugs Appear to Have a Genetic Resistance to Pesticides : ScienceAlert
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In a groundbreaking discovery, researchers have found a mutation in the genome of the common bed bug that allows them to survive the chemical onslaught of insecticides. This mutation, known as the A302S Rdl gene mutation, causes an amino acid substitution in chemical pathways associated with the nervous system, providing the bed bugs with resistance to lethal toxins found in exterminator sprays.

The study, led by entomologists from Virginia Polytechnic Institute and State University, analyzed bed bug populations from across the United States and Canada. They found that two bugs with the A302S Rdl gene mutation were able to survive exposure to insecticides, similar to the resistance seen in German cockroaches.

The A302S Rdl gene mutation is associated with resistance to dieldrin, an insecticide developed as an alternative to DDT in the 1940s. Although dieldrin has been banned since the 1980s due to its environmental persistence and health risks, the similarity in composition between dieldrin and fipronil, a current insecticide used against household pests, has led to cross-resistance in bed bugs.

Fipronil, while considered a more acceptable option due to its shorter half-life, still poses risks to bee colonies and other wildlife. The researchers discovered that bed bugs with the A302S Rdl gene mutation were also resistant to fipronil, highlighting the adaptability of these pests to chemical treatments.

The evolutionary timeline of this mutation in bed bugs remains unclear, as exposure to dieldrin and fipronil has been ongoing for decades. Further studies using genetic sequencing of bed bug populations from various locations and time periods aim to shed light on the development and spread of this resistance.

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Published in the Journal of Medical Entomology and Journal of Heredity, this research provides valuable insights into the mechanisms of insecticide resistance in bed bugs. As these pests continue to pose challenges for pest control professionals and homeowners alike, understanding the genetic basis of their resilience is crucial for developing effective strategies to manage infestations.

TAGGED:BedBugsgeneticpesticidesresistanceScienceAlert
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