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American Focus > Blog > Tech and Science > Da Vinci’s Genetic Secrets May Soon Be Revealed by Ambitious DNA Project
Tech and Science

Da Vinci’s Genetic Secrets May Soon Be Revealed by Ambitious DNA Project

Last updated: September 22, 2025 2:38 pm
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Da Vinci’s Genetic Secrets May Soon Be Revealed by Ambitious DNA Project
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Scientists from the Leonardo DNA Project are making remarkable strides in their quest to reconstruct the DNA of the legendary 16th-century artist and thinker, Leonardo da Vinci. Known as a polymath of the Renaissance, da Vinci’s influence permeates various fields, including art, science, and anatomy.

Recent announcements highlight significant advancements in the project, with genetic confirmations revealing a male bloodline linked to da Vinci tracing back to 1331. This news is part of an ongoing ambition that has spanned nearly ten years and aims to solidify da Vinci’s final resting place.

Achieving this milestone could pave the way for the genetic sequencing of the Renaissance genius’s genome, an endeavor that holds vast potential for insights.

Related: Hidden Detail in Crotch Solves 500-Year-Old Leonardo Da Vinci Mystery

The project aims to leverage these findings to “better understand [da Vinci’s] extraordinary talents and visual acuity through genetic associations.” This knowledge may even allow scientists to recreate a three-dimensional likeness of da Vinci.

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A significant breakthrough in locating da Vinci’s genetic lineage was achieved by genealogists Alessandro Vezzosi and Agnese Sabato from the Leonardo Da Vinci Heritage Association. Their extensive research has revealed new developments coinciding with the launch of their book, Genìa Da Vinci. Genealogy and Genetics for Leonardo’s DNA.

Leading the project, molecular anthropologist David Caramelli, alongside forensic anthropologist Elena Pilli, tested DNA from six contemporary descendants within the da Vinci family. Results showed matching segments in their Y chromosomes, confirming a lineage that extends at least 15 generations into the past.

With a potential family line identified, the next step involves comparison with DNA samples from Leonardo’s presumed remains and those of potential relatives. Historical records suggest that da Vinci, who passed away in May 1519, was buried in the Church of Saint Florentin in Amboise, a site that no longer exists due to the French Revolution.

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The bones believed to belong to da Vinci were recovered in 1863 and were relocated to a modest chapel in the Loire Valley. Skepticism surrounding the authenticity of these remains has lingered, especially since da Vinci had no children.

Vezzosi and Sabato meticulously traced the male descendants of da Vinci’s father and half-brother, reportedly identifying 15 potential relatives. An exciting development from the DNA Project includes a planned excavation of a family tomb, which may hold the remains of Leonardo’s grandfather, uncle, and half-brothers. This excavation is led by University of Florence anthropologists Alessandro Riga and Luca Bachechi, who have preliminary findings suggesting the presence of at least one male set of remains.

“Further detailed analyses are necessary to determine whether the DNA extracted is sufficiently preserved,” Caramelli stated. “Based on the results, we can proceed with analysis of Y chromosome fragments for comparison with current descendants.”

Establishing a genetic link between the DNA of living descendants and the excavated remains would bolster the case for confirming the family line of da Vinci. While there remains a considerable journey ahead before definitive conclusions can be drawn, the progress towards reconstructing da Vinci’s DNA is an exciting prospect.

Vezzosi expressed hope that “through the recovery of Leonardo’s DNA, we aim to delve into the biological roots of his exceptional visual acuity, creativity, and potentially explore facets of his health and causes behind his death.”

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