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American Focus > Blog > Tech and Science > Doctors Discover New Blood Type—And Only One Person Has It
Tech and Science

Doctors Discover New Blood Type—And Only One Person Has It

Last updated: July 15, 2025 11:25 am
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Doctors Discover New Blood Type—And Only One Person Has It
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French scientists have made a groundbreaking discovery in the world of blood types, identifying the newest and rarest blood group known as “Gwada-negative”. This unique blood group was found in a woman from Guadeloupe, whose blood did not match with any potential donor samples, making it impossible to find a suitable donor for her.

The discovery of the 48th recognized blood group, Gwada-negative, began when the woman’s blood plasma reacted against every donor sample tested, including those from her siblings. This led scientists to conduct genetic analysis using whole exome sequencing, which revealed a mutation in a gene called PIGZ. This mutation resulted in the absence of a specific sugar on the surface of red blood cells, creating a new antigen and classifying the blood type as Gwada-positive or -negative.

Further experimentation confirmed the uniqueness of the Guadeloupian woman’s blood, as she is currently the only known Gwada-negative individual in the world. The implications of this discovery go beyond blood transfusions, as the patient also suffers from mild intellectual disability and has experienced tragic outcomes such as losing two babies at birth, which may be linked to her rare genetic mutation.

The enzyme produced by the PIGZ gene plays a crucial role in building a complex molecule called GPI (glycosylphosphatidylinositol). Previous research has shown that defects in enzymes involved in GPI assembly can lead to neurological problems and stillbirths. While this rare blood type poses challenges in finding compatible donors, researchers are exploring the possibility of using lab-grown blood cells to match ultra-rare blood types like Gwada-negative.

The discovery of Gwada-negative adds to the 47 other blood group systems recognized by the International Society of Blood Transfusion. As genetic sequencing technology advances, more rare blood types are expected to be uncovered, shedding light on human variation and presenting new challenges for personalized medicine.

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This groundbreaking discovery highlights the marvels and challenges of human genetic diversity, emphasizing the importance of ongoing research in the field of blood types and transfusions. By delving into the intricacies of blood group systems, scientists are paving the way for a better understanding of human biology and personalized healthcare.

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