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American Focus > Blog > Health and Wellness > Gender-affirming care report author decries ‘misuse’ of his work
Health and Wellness

Gender-affirming care report author decries ‘misuse’ of his work

Last updated: September 22, 2025 10:00 am
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Gender-affirming care report author decries ‘misuse’ of his work
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But in many instances, we still provide the care based on what we know, even if the evidence is limited. For example, in cases where a patient is in critical condition and there are no well-conducted studies available, doctors will still make decisions based on their clinical experience and knowledge. In these situations, the best available evidence may not be perfect, but it’s still better than making decisions without any evidence at all.

How do you respond to critics who say that the low certainty of evidence in these reviews means that gender-affirming care should not be provided?

I would say that these critics are misinterpreting the findings. Low certainty evidence doesn’t mean that something doesn’t work or shouldn’t be provided. It simply means that we need more research to better understand the benefits and risks of the intervention. In the case of gender-affirming care, there is anecdotal evidence from individuals who have undergone these therapies and have reported significant improvements in their well-being and quality of life. This should not be discounted.

Furthermore, denying care to individuals who are seeking gender-affirming treatments based on limited evidence is not only unjust, but it can also have serious consequences on their mental health and overall well-being. It’s important to approach these decisions with compassion and an understanding of the complexities involved.

What do you hope will come out of the discussions surrounding these reviews?

My hope is that these reviews will spark more research in the field of gender-affirming care for children and young adults. We need high-quality studies that can provide us with better evidence to guide clinical practice. In the meantime, it’s crucial that we approach these decisions with empathy and a commitment to providing the best possible care for all individuals, regardless of their gender identity.

Gordon Guyatt’s work on systematic reviews has always been aimed at improving patient care and outcomes. Despite the controversy surrounding these particular reviews, his commitment to evidence-based medicine remains unwavering. As discussions continue around gender-affirming care, it’s important to consider the needs and well-being of those seeking these treatments above all else.

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It ensures that the treatment is closely monitored and evaluated, which can provide valuable data on its efficacy and potential risks. However, it also restricts access to care for young people who may benefit from it.

The issue of evidence in gender-affirming care is complex and challenging. As with many medical interventions, the evidence base is often limited or of low quality. This poses a significant challenge for healthcare providers, policymakers, and individuals seeking care in making informed decisions.

As highlighted in the case of the mountain biker who sought advice from various healthcare professionals following an accident, the lack of high-quality evidence does not necessarily mean that a treatment or intervention is ineffective. It simply means that more research is needed to fully understand its benefits and risks.

In the context of gender-affirming care, where decisions can have profound and long-lasting effects on individuals’ lives, the need for high-quality evidence is paramount. As seen in the controversy surrounding the misuse of research findings to support legislative decisions, the stakes are high, and the consequences of inadequate evidence can be harmful.

Moving forward, it is essential to prioritize rigorous research and evidence-based practice in the field of gender-affirming care. This includes conducting high-quality randomized controlled trials, systematic reviews, and other research studies to establish the safety and efficacy of different interventions.

In the absence of high-quality evidence, healthcare providers should approach gender-affirming care with caution, making decisions based on the best available evidence, expert consensus, and individual patient preferences. Additionally, policymakers should be mindful of the limitations of the evidence base when making decisions that impact access to care for transgender and gender-diverse individuals.

Ultimately, improving the evidence base for gender-affirming care is crucial to ensuring that individuals receive safe, effective, and affirming care that meets their unique needs. By investing in research and prioritizing evidence-based practice, we can work towards a future where all individuals have access to high-quality, evidence-based care that supports their health and well-being. In the realm of healthcare, the issue of gender dysphoria has sparked heated debates and differing opinions on the best course of treatment. Recently, a U.S. Department of Health and Human Services report cited the work of experts in the field, shedding light on the various perspectives surrounding gender-affirming care. This report was just one of several major publications on the topic, including the Cass Review from the U.K., a report from Utah lawmakers who had passed a state ban on such care, and a report from medical societies in Germany, Austria, and Switzerland. Despite being based on the same body of evidence, these reports came to varying conclusions, leaving many to wonder how such discrepancies could arise.

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Dr. Joshua Safer, a prominent figure in the field, offers insights into why different reports may draw different conclusions. He highlights two primary reasons for disagreement among experts – interpretation of the evidence and differing values and preferences. While some may view the evidence as inconclusive regarding the benefits of gender-affirming therapies, others argue that there is clear evidence of positive outcomes for individuals who undergo such treatments. This discrepancy in interpretation can lead to conflicting conclusions on the efficacy of gender-affirming care.

Moreover, values and preferences play a significant role in shaping opinions on this topic. Dr. Safer emphasizes the importance of considering the autonomy of individuals seeking gender-affirming care, as well as the potential harm that may result from denying them access to such treatments. He points out that while some may prioritize avoiding harm to a minority of individuals who may be negatively impacted by these therapies, others place a higher value on respecting the autonomy and well-being of those who could benefit from gender-affirming care.

Critics have accused Dr. Safer of straying from scientific evidence and taking a political stance on the issue. However, he clarifies that his involvement in clinical practice guidelines is rooted in a scientific approach to decision-making. By considering both the available evidence and the values and preferences at play, Dr. Safer advocates for a comprehensive understanding of the complex issues surrounding gender dysphoria and the need for individualized care that respects the autonomy and well-being of all individuals seeking treatment.

In conclusion, the debate surrounding gender-affirming care is multifaceted and influenced by a variety of factors, including differing interpretations of evidence and conflicting values and preferences. By acknowledging these complexities and engaging in thoughtful dialogue, healthcare professionals can work towards providing inclusive and effective care for individuals with gender dysphoria. The impact of social media on mental health has been a topic of much debate in recent years. With the rise of platforms like Facebook, Instagram, and Twitter, people are more connected than ever before. However, this constant connection can have negative effects on our mental well-being.

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One of the main ways that social media affects mental health is through comparison. When we scroll through our feeds, we are bombarded with images of people living seemingly perfect lives. This can lead to feelings of inadequacy and low self-esteem as we compare ourselves to others. Research has shown that frequent use of social media is associated with higher levels of depression and anxiety.

Another way that social media can impact mental health is through cyberbullying. With the anonymity that the internet provides, people feel emboldened to say hurtful things online that they would never say in person. This can have serious consequences for the mental health of the victims, leading to feelings of isolation and worthlessness.

Additionally, the constant stimulation of social media can lead to addiction. The dopamine hit that we get from likes, comments, and shares can create a cycle of seeking validation from others. This can lead to a decrease in real-world interactions and an over-reliance on social media for emotional support.

Despite these negative effects, social media can also have positive impacts on mental health. It can provide a sense of community for people who may feel isolated in their daily lives. It can also be a source of support and encouragement for those going through tough times.

Overall, it is important to be mindful of our social media use and its impact on our mental health. Setting boundaries, taking breaks, and seeking support when needed can help mitigate the negative effects of social media. By being mindful of how we engage with social media, we can ensure that it remains a positive force in our lives.

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