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American Focus > Blog > Health and Wellness > GLP-1 obesity drug effective for kids, raising hope and concern| STAT
Health and Wellness

GLP-1 obesity drug effective for kids, raising hope and concern| STAT

Last updated: September 10, 2024 6:51 pm
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GLP-1 obesity drug effective for kids, raising hope and concern| STAT
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The first late-stage trial of a GLP-1 drug in young children with obesity has shown promising results in lowering body mass index (BMI). Novo Nordisk’s Saxenda, also known as liraglutide, was tested in children aged 6 to 12, alongside lifestyle interventions. The study found that children who received daily injections of Saxenda experienced a 5.8% decrease in BMI compared to a 1.6% increase in the placebo group. Additionally, blood pressure and blood sugar levels improved more in children receiving the drug.

However, the study also revealed some concerning findings. When children stopped taking Saxenda, their BMI started to rise again, indicating that continuous medication may be necessary to sustain weight loss effects. Children on the drug also experienced a higher rate of side effects, particularly gastrointestinal issues like nausea and vomiting. Some children even had to discontinue treatment due to side effects. These results have raised questions about the safety and long-term effects of using obesity medications in young children.

The drugmakers behind GLP-1 medications have been conducting trials in various populations, including children. Novo Nordisk has sought regulatory approval to expand Saxenda’s label to children as young as 6, pending the results of this trial. The company is also testing Wegovy, a stronger GLP-1, in the same age group. Eli Lilly is studying its obesity treatment Zepbound in children as well.

The potential benefits of treating childhood obesity early on to prevent future health issues have been highlighted by experts. However, there are concerns about the risks associated with giving medications to young children. Some doctors worry about the lack of data on the long-term effects of these drugs on development and puberty. There is also a fear that medications affecting food intake could increase the risk of eating disorders in children.

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The debate on how to address obesity in children and adolescents has been ongoing. While some experts advocate for the use of medications as a tool in the treatment of obesity, others emphasize intensive behavioral interventions over drugs. The recent findings from the trial of young children with Saxenda have reignited this debate. Some doctors believe that early intervention with medications could have significant benefits, while others are cautious about the potential risks and prefer focusing on lifestyle changes.

Overall, the study of Saxenda in young children has provided valuable insights into the effectiveness and safety of using GLP-1 drugs in this population. As more data is collected from ongoing studies, it will be crucial to weigh the benefits and risks of using obesity medications in children to determine the best approach for managing childhood obesity. Melissa Crocker, the clinical chief of endocrinology at Boston Children’s Hospital, has raised concerns about the potential long-term consequences of using medications to address childhood obesity. She highlighted the possible impact on mental health, especially in younger children who may struggle to understand the need for medication. Crocker emphasized the importance of balancing the prevention of physical health issues associated with obesity with the potential harm to a child’s mental well-being.

She pointed out that introducing injectable medications on a daily basis could create a sense of sickness in children and contribute to feelings of inadequacy or stigma surrounding their weight. The risk of developing eating disorders, although more common in adolescents, is also a concern for younger children who may not fully comprehend the reasons behind their weight-related concerns.

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Crocker emphasized the need to promote body positivity and acceptance of diverse body shapes and sizes while still addressing metabolic health issues. She acknowledged the challenge of predicting the specific medical complications that individuals may face due to their weight, further underscoring the complexity of managing childhood obesity.

In addition to the concerns about the impact on children, Crocker also expressed empathy for parents navigating the complexities of addressing their children’s weight. She highlighted the frustration parents may feel when traditional advice, such as encouraging more physical activity, does not lead to desired outcomes.

As the debate around childhood obesity guidelines continues, it is essential to consider not only the physical health implications but also the potential mental health consequences of interventions. Finding a balance between promoting overall well-being and addressing weight-related concerns remains a critical challenge in pediatric care.

This article was rewritten based on a statement made by Melissa Crocker, and it underscores the importance of considering the long-term effects of interventions in childhood obesity management.

TAGGED:concernDrugEffectiveGLP1hopeKidsObesityRaisingSTAT
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