The Last of Us: Climate Change and the Rise of Fungal Infections
The premise of The Last of Us video game and upcoming TV series revolves around a fungus that mutates due to climate change, infecting humans and turning them into deadly zombies. While this may seem like pure fiction, there are real concerns about the spread of fungal infections linked to climate change.
Scientists are sounding the alarm about the proliferation of Aspergillus fungi, which thrive in warmer temperatures exacerbated by climate change. While these fungi don’t create zombies, they can pose serious health risks to humans, animals, and plants.
A recent study from the UK highlights the potential spread of three Aspergillus species – Aspergillus fumigatus, Aspergillus flavus, and Aspergillus niger – towards more northern regions by 2100, driven by climate models predicting future warming.

Environmental mycologist Norman van Rhijn from the University of Manchester warns that changes in humidity and extreme weather events due to climate change can drive fungal adaptation and spread. The study projects a significant increase in the spread of Aspergillus fungi in Europe, putting millions more people at risk of infection.
While the overall number of people exposed to these fungi may decline by 2100, the expansion into new areas poses a threat, especially to vulnerable populations with weakened immune systems. The implications extend beyond human health, with fungal outbreaks jeopardizing crop production and food security in a changing climate.
Researchers emphasize the need for heightened awareness and effective interventions to combat fungal pathogens in the face of climate change. Understanding the dual nature of fungi – as both potential threats and essential components of ecosystems – is crucial for addressing the shifting landscape of infectious diseases.
Although the study is not yet peer-reviewed, it offers valuable insights into the intersection of climate change and fungal infections. For more details, the preprint of the study is available on Research Square.