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American Focus > Blog > Tech and Science > How a surge in ancient plagues 5000 years ago shaped humanity
Tech and Science

How a surge in ancient plagues 5000 years ago shaped humanity

Last updated: October 29, 2025 2:10 am
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New Scientist. Science news and long reads from expert journalists, covering developments in science, technology, health and the environment on the website and the magazine.

Recent discoveries in the field of disease history have shed light on ancient human DNA samples, revealing the presence of genes from the plague bacterium, Yersinia pestis, dating back to 5000 years ago in Eurasia. This finding challenges previous beliefs about the emergence and spread of contagious diseases, suggesting that major outbreaks occurred much earlier than previously thought.

One significant revelation is the Late Neolithic-Bronze Age (LNBA) plague, which appears to have had a substantial impact on the population during that period. Researchers have analyzed ancient human remains to uncover traces of various pathogens, including typhoid, hepatitis B, syphilis, and smallpox, dating back thousands of years. This extensive study, led by population geneticist Martin Sikora, has provided valuable insights into the evolution of pathogens and the adaptation of the human immune system over time.

The arrival of nomadic herders known as the Yamnaya in Europe around 5000 years ago coincides with a surge in infectious diseases. These herders, with their lifestyle of large herds and close proximity to animals, likely played a role in the transmission of zoonotic diseases to humans. The spread of diseases like plague, relapsing fever, and leprosy among ancient populations has raised questions about the impact of these pathogens on the prehistoric world.

Studies have suggested that plague may have been airborne or transmitted through the consumption of infected meat, rather than by fleas as seen in the Black Death. The genetic adaptation of Europeans to infectious diseases around 6000 years ago and the spread of immunity-related genetic variants around 4500 years ago indicate a significant evolutionary response to the prevalence of diseases during that time.

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While the exact role of plague in the Neolithic decline remains debated, its potential influence on population dynamics and cultural evolution cannot be ignored. The interaction between pathogens and human populations in ancient times has left a lasting impact on our genetic makeup and susceptibility to certain diseases today.

By delving into the past, researchers aim to unravel the mysteries of our evolutionary history and better understand the implications of ancient diseases on modern health challenges. The study of infectious diseases in prehistoric populations offers valuable insights into human resilience, genetic adaptation, and the ongoing battle against emerging diseases.

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