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American Focus > Blog > Tech and Science > How THC, the Psychoactive Compound in Weed, Gets You High
Tech and Science

How THC, the Psychoactive Compound in Weed, Gets You High

Last updated: April 18, 2025 3:12 pm
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How THC, the Psychoactive Compound in Weed, Gets You High
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Marijuana is a complex plant that contains more than 500 active compounds, but the two most well-known are cannabidiol (CBD) and tetrahydrocannabinol (THC). CBD is known for its anti-inflammatory properties, while THC is the main psychoactive component responsible for the “high” sensation associated with consuming marijuana.

THC, which stands for tetrahydrocannabinol, is primarily found in the flowers of female cannabis plants, although it can also be found in other parts of the plant. In its raw form, THC exists as tetrahydrocannabinolic acid (THCA), which does not have psychoactive effects. However, when cannabis is heated, vaporized, or exposed to sunlight, THCA is converted into THC, which is then able to enter the bloodstream when consumed through smoking, vaping, dabbing, or eating edibles.

Once in the bloodstream, THC crosses the blood-brain barrier and binds to cannabinoid receptors in the brain, affecting various functions such as memory, appetite, fear, and motor control. THC can impact short-term memory, alter perception of time, increase appetite, and trigger the release of dopamine, leading to feelings of pleasure.

Historically, cannabis has been used for medicinal purposes for thousands of years in various cultures around the world. However, in the early 20th century, negative perceptions of marijuana led to its criminalization in many countries, including the United States. Despite these legal restrictions, research on marijuana has been limited due to government regulations.

In recent years, there has been a growing interest in studying the potential medical benefits of THC and other cannabinoids found in cannabis. With new legislation allowing for more research on cannabis, scientists hope to explore different types of THC, such as delta-8-THC and delta-10-THC, which have milder effects compared to traditional THC.

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By lifting restrictions on cannabis research, scientists aim to better understand the specific medical benefits of THC and explore new applications for its use. This increased focus on scientific research could provide valuable insights into the potential therapeutic effects of THC and other compounds found in marijuana.

TAGGED:CompoundHighPsychoactiveTHCweed
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