Eric Dane and Alyssa Milano’s friendship was one that stood the test of time, starting as a brief romance in the early 2000s and evolving into a decades-long bond. The two dated before Dane landed a role on the hit TV show Charmed, which Milano starred in alongside Holly Marie Combs and Rose McGowan. Despite their split, Dane went on to marry Rebecca Gayheart in 2004, while Milano tied the knot with David Bugliari in 2009.
Over the years, Dane and Milano remained close, with their friendship enduring even after Dane was diagnosed with ALS in April 2025. Tragically, the Grey’s Anatomy actor passed away in 2026 at the age of 53. Milano paid tribute to her late friend on Instagram, reminiscing about his sharp sense of humor and infectious personality.
Their friendship was a special one, filled with cherished memories and shared experiences. From their time together in the early 2000s to Dane’s guest appearances on Charmed, their connection was evident to those around them. In a podcast interview in 2024, Dane reflected on their past relationship, highlighting Milano’s kindness and warmth.
After Dane’s passing, Milano shared a heartfelt message on social media, expressing her condolences to his family and reflecting on the impact he had on her life. She remembered his love for his daughters and wife, as well as the moments they shared together that shaped her in profound ways.
Their bond was a testament to the power of friendship and the lasting impact two people can have on each other’s lives. As Milano honored Dane’s memory, she also celebrated the moments they shared and the love they had for each other. Their friendship will always be remembered as a shining example of true connection and mutual respect.
