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American Focus > Blog > Health and Wellness > It’s past time to end HIV wonder drug experimentation in Africa
Health and Wellness

It’s past time to end HIV wonder drug experimentation in Africa

Last updated: September 18, 2024 9:42 pm
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It’s past time to end HIV wonder drug experimentation in Africa
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At the recent annual International AIDS Conference, a groundbreaking presentation about the latest wonder drug in HIV prevention received a thunderous standing ovation. Lenacapavir, a revolutionary drug administered as an injection under the skin every six months, demonstrated a 100% success rate in preventing HIV in adolescent girls and young women in two African countries.

The announcement of this achievement felt like a significant moment in the fight against HIV. After numerous unsuccessful vaccine trials, the introduction of a biannual shot that significantly reduces HIV infections was a major breakthrough. The fact that the drug showed such remarkable efficacy in young women in Africa added to the significance of the findings.

However, amidst the celebration, some members of the public health community began to question the lack of clarity regarding the process of making this drug accessible to young women in Africa. While the scientific results were impeccable, the pathway to translating those results into action for the benefit of the African population seemed uncertain. Gilead, the manufacturer of lenacapavir, initially stated that it was too early to discuss licensing and provided vague plans for production and availability in Africa. Despite promising results in a second study among men who have sex with men, conducted predominantly in the Northern Hemisphere, Gilead has yet to provide a definitive timeline for licensing and manufacturing the drug worldwide.

Lenacapavir, with an estimated manufacturing cost of around $40 per year, is currently licensed as an HIV treatment for over $42,000 per year in the United States. In South Africa, where public healthcare expenditures are approximately $230 per person per year, advocates and study scientists have urged Gilead to make the drug promptly available in sub-Saharan Africa at an affordable price. With over 3,000 women becoming infected with HIV each week in the region, the need for urgent action is undeniable.

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This situation is reminiscent of previous instances where HIV prevention wonder drugs, such as Cabotegravir, have been tested in young African women but remain largely unavailable in the region. Despite showing over 90% effectiveness in preventing new HIV infections, Cabotegravir is not expected to be widely available in Africa until at least 2027, nine years after the study began.

The repeated testing of HIV therapies in African populations highlights the urgent need for a new approach to drug development research in low- and middle-income settings. A policy that requires a licensing, manufacturing, pricing, and distribution plan to be established prior to conducting trials could ensure timely access to effective treatments for the communities involved. This proactive approach would shift the balance of power between participants in drug trials and pharmaceutical companies, ensuring that those who volunteer to participate in studies are promptly provided access to beneficial treatments.

In conclusion, while the availability of lenacapavir in Africa remains uncertain, it is evident that a new policy framework is needed to ensure timely access to life-saving medications for vulnerable populations. By establishing clear timelines for local licensing and manufacturing, we can ensure that future wonder drugs quickly reach those who need them the most. It is time for a paradigm shift in drug development research to prioritize the well-being of study participants and their communities.

TAGGED:AfricaDrugexperimentationHIVtime
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