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American Focus > Blog > Health and Wellness > Less processed diet may be more beneficial for weight loss, clinical trial indicates
Health and Wellness

Less processed diet may be more beneficial for weight loss, clinical trial indicates

Last updated: August 4, 2025 7:20 pm
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Less processed diet may be more beneficial for weight loss, clinical trial indicates
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The importance of choosing minimally processed foods over ultra-processed foods for weight loss and overall health has been highlighted in a new clinical trial conducted by researchers at University College London (UCL) and UCLH. The study, published in Nature Medicine, compared the effects of ultra-processed food (UPF) and minimally processed food (MPF) diets on weight and cardiometabolic health.

In the trial, 55 adults were split into two groups and provided with nutritionally matched diets based on the UK’s official dietary guidelines. One group started with an eight-week diet of MPF, such as homemade spaghetti Bolognese, while the other group started with a diet of UPF, such as ready meals. After a four-week period, the groups switched diets. The diets were delivered to participants’ homes, and they were instructed to eat as much or as little as they wanted.

The results showed that participants lost twice as much weight on the MPF diet compared to the UPF diet. The weight loss on the MPF diet was attributed to reductions in fat mass and total body water, with no change in muscle or fat-free mass, indicating a healthier body composition overall. The study also found that participants reported greater improvements in food cravings and craving control on the MPF diet.

Dr. Samuel Dicken, the lead author of the study, emphasized the importance of choosing minimally processed foods for weight loss and overall health. He pointed out that following nutritional guidelines and opting for whole foods over ultra-processed options can lead to significant improvements in weight and body composition.

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Professor Chris van Tulleken, one of the authors of the study, highlighted the need for policy changes to address the influence of multinational food companies on unhealthy food environments. He stressed the importance of making healthy diets affordable, available, and desirable for all individuals.

In conclusion, the study suggests that choosing minimally processed foods over ultra-processed foods can be more effective for weight loss and overall health. By following nutritional guidelines and prioritizing whole foods, individuals can improve their body composition and reduce the risk of diet-related health issues. This research underscores the importance of making informed food choices and advocating for policy changes to promote healthier food environments.

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