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American Focus > Blog > Sports > NFL Week 16 DFS lineup advice feat. J.J. McCarthy, Audric Estime, Mike Evans and More
Sports

NFL Week 16 DFS lineup advice feat. J.J. McCarthy, Audric Estime, Mike Evans and More

Last updated: December 19, 2025 9:35 am
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NFL Week 16 DFS lineup advice feat. J.J. McCarthy, Audric Estime, Mike Evans and More
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The NFL season may be over for your season-long fantasy team, but that doesn’t mean you can’t still get in on the action and make some real cash in Daily Fantasy Sports. With multiple slates to choose from, the DraftKings Sunday main slate offers plenty of opportunities to build a winning lineup.

If you’re looking for some guidance on setting your DFS lineup, look no further. I’ve put together a list of my favorite players to target for this weekend’s slate. From quarterbacks to tight ends to defenses, I’ve got you covered.

Quarterback

  • Jacoby Brissett ($5300): Brissett leads the league in dropbacks and has been a consistent top-12 finisher in fantasy points this season. Facing a Falcons defense that has struggled against the pass, Brissett is a solid option for a mid-range price. Consider stacking him with Trey McBride or other affordable options like Michael Wilson or Marvin Harrison Jr.
  • J.J. McCarthy ($4900): McCarthy has put up back-to-back 20+ point performances and faces a weak Giants defense this week. With the ability to pick up yards on the ground as well, McCarthy is a value play with upside. Pair him with Justin Jefferson for a potentially high-scoring stack.

    Running Back

  • De’Von Achane ($8800): Priced as the most expensive back on the slate, Achane is worth the investment. With a favorable matchup against the Bengals, who allow the most fantasy points to running backs, Achane should have a big game.
  • Audric Estime ($5000): If you’re looking to save some salary, Estime is a solid option. With a chance to see increased touches in the absence of Devin Neal, Estime offers value at his price point.

    Wide Receiver

  • Mike Evans ($6300): Coming off a strong performance in his return from injury, Evans is a reliable option in the Bucs’ passing game. Facing a Panthers defense that may focus on other threats, Evans could see plenty of targets and red zone opportunities.
  • Chris Olave ($6500): With consistent target volume and a favorable matchup against the Jets, Olave is a solid play at his price. Look for him to exploit a weak secondary and put up big numbers.

    Tight End

  • Harold Fannin Jr. ($4500): Despite a tough matchup against the Bills, Fannin’s usage in the Browns’ passing game makes him an intriguing option. With a solid target share in recent weeks, Fannin has the potential to outperform his price tag.

    Defense

  • Texans ($4000): The Texans are the most expensive defense on the slate, but they face a struggling Raiders offense and have a chance to put up big fantasy points. Consider spending up for a high-floor option.
  • Falcons ($2700): For a cheaper option, the Falcons face a Cardinals offense that has struggled to protect their quarterback. With the potential for sacks and turnovers, the Falcons defense offers value at their price point.

    So if you’re looking to make some money in Daily Fantasy Sports this weekend, consider building your lineup around these players. With the right combination of value plays and high-upside options, you could be on your way to a big payday. Good luck, and may your lineup bring you success on the Sunday main slate.

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