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American Focus > Blog > Tech and Science > No, There Isn’t a Mysterious Brain Disease Spreading in Canada : ScienceAlert
Tech and Science

No, There Isn’t a Mysterious Brain Disease Spreading in Canada : ScienceAlert

Last updated: May 14, 2025 3:00 pm
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No, There Isn’t a Mysterious Brain Disease Spreading in Canada : ScienceAlert
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Study Finds No Evidence of New Disease in New Brunswick Brain Illness Cases

Reports of a mysterious brain illness in New Brunswick, Canada have been making headlines since 2019, but a recent study assessing these cases has found no evidence of a new disease spreading.

Researchers from various Canadian institutions reevaluated 25 cases of the so-called New Brunswick neurological syndrome of unknown cause (NSUC), examining 14 living patients and conducting brain autopsies on 11 deceased individuals.

Upon closer inspection, the researchers concluded that the symptoms reported in these cases could be attributed to existing conditions such as Alzheimer’s, Parkinson’s, and traumatic brain injury, debunking the notion of a new emerging disease.

The study highlighted that incorrect interpretations of patient histories, misinterpretations of physical examinations, and reliance on tests unrelated to brain conditions led to the misconception of a new disease.

According to the researchers, all 25 cases were linked to well-known neurological disorders, as detailed in their published paper in JAMA Neurology.

Common symptoms reported by affected individuals included anxiety, visual hallucinations, limb pain, and rapidly progressing dementia, with over 500 unofficial cases reported despite the official count standing at 222.

Brain scans
The researchers were able to link each case to a known brain condition. (Bendahan et al., JAMA Neurology, 2025)

Various theories have been proposed to explain the situation, ranging from environmental pollution to a potential prion-related disease. Media coverage has fueled concerns of a mystery illness, but the study’s findings refute these claims.

Despite the research findings, some individuals involved in the cases remain skeptical, with some refusing second opinions or failing to respond to the study authors’ communications. A previous expert report from 2022 also concluded that no unexplained syndrome was involved.

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Recent calls for a renewed investigation into the illnesses have emerged, indicating that the issue is not fully resolved. The researchers emphasize the importance of thorough evaluations for any new cases of NSUC.

The study has been published in JAMA Neurology and underscores the need for independent clinical assessments in diagnosing NSUC.

TAGGED:brainCanadadiseaseIsntMysteriousScienceAlertspreading
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