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American Focus > Blog > Tech and Science > OpenAI’s latest AI models have a new safeguard to prevent biorisks
Tech and Science

OpenAI’s latest AI models have a new safeguard to prevent biorisks

Last updated: April 16, 2025 2:23 pm
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OpenAI’s latest AI models have a new safeguard to prevent biorisks
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OpenAI Implements New System to Monitor AI Models for Biological and Chemical Threats

OpenAI has announced the deployment of a new monitoring system for its latest AI reasoning models, o3 and o4-mini, specifically targeting prompts related to biological and chemical threats. The primary objective of this system is to prevent the models from providing advice that could potentially lead to harmful actions, as outlined in OpenAI’s safety report.

The introduction of o3 and o4-mini represents a significant advancement in capabilities compared to OpenAI’s previous models. However, this also brings about new risks, particularly in the hands of malicious actors. According to internal benchmarks, o3 demonstrates enhanced proficiency in addressing questions related to the creation of certain biological threats. In response to these potential risks, OpenAI has developed a specialized monitoring system described as a “safety-focused reasoning monitor.”

The monitoring system, trained to align with OpenAI’s content policies, operates on top of the o3 and o4-mini models. Its primary function is to identify prompts associated with biological and chemical risks and prompt the models to refrain from providing advice on these topics.

To establish a baseline for the monitoring system, OpenAI enlisted red teamers to spend approximately 1,000 hours flagging “unsafe” conversations related to biorisks from o3 and o4-mini. During a test simulation of the monitor’s “blocking logic,” the models successfully declined to respond to risky prompts 98.7% of the time, indicating the effectiveness of the system.

While acknowledging the limitations of the test, OpenAI recognizes the possibility of users attempting new prompts after being blocked by the monitor. Therefore, the company plans to maintain human monitoring alongside the automated system.

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Although o3 and o4-mini do not surpass OpenAI’s threshold for “high risk” biorisks, early versions of these models exhibited greater proficiency in addressing queries related to developing biological weapons compared to previous models like o1 and GPT-4.


Chart from o3 and o4-mini’s system card (Screenshot: OpenAI)

OpenAI remains vigilant in monitoring how its models could potentially facilitate the creation of chemical and biological threats, as outlined in the company’s updated Preparedness Framework.

Furthermore, OpenAI is increasingly leveraging automated systems to mitigate risks associated with its models. For instance, to prevent GPT-4o’s native image generator from generating child sexual abuse material (CSAM), a similar reasoning monitor to the one deployed for o3 and o4-mini is utilized.

Despite these efforts, some researchers have expressed concerns about OpenAI’s safety prioritization. One of the company’s red-teaming partners, Metr, highlighted the limited testing time for o3 on a deceptive behavior benchmark. Additionally, OpenAI opted not to release a safety report for its GPT-4.1 model, which was recently launched.

TAGGED:biorisksLatestmodelsOpenAIsPreventsafeguard
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