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American Focus > Blog > Tech and Science > Researchers genetically altered fruit flies to crave cocaine
Tech and Science

Researchers genetically altered fruit flies to crave cocaine

Last updated: June 2, 2025 5:16 pm
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Researchers genetically altered fruit flies to crave cocaine
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Scientists at the University of Utah have made a groundbreaking discovery by engineering fruit flies that are susceptible to cocaine addiction. While this may sound bizarre, there are important reasons behind this genetic modification. The engineered fruit flies could potentially revolutionize addiction treatment therapies and accelerate research efforts in this field. The findings of this study have been published in the Journal of Neuroscience.

Fruit flies share around 70-75 percent of the same genes with humans, making them an ideal genetic model for studying various diseases, including addiction. Their rapid life cycle and simple genetic makeup have made them invaluable in research, particularly in investigating the biological basis of drug abuse such as cocaine addiction. However, until now, fruit flies have shown a strong aversion to cocaine.

Adrian Rothenfluh, the senior author of the study, explained that even when exposed to cocaine, the fruit flies consistently chose pure sugar water over cocaine-laced sugar water. This behavior was attributed to the flies’ taste receptors located on their legs, which are evolutionarily designed to avoid plant toxins like cocaine.

To overcome this aversion, the researchers deactivated the bitter-sensing taste receptors in the fruit flies. Once these nerves were switched off, the flies readily developed a preference for cocaine-infused sugar water. Within 16 hours of exposure, the modified flies showed a clear preference for the drug-laced drink, exhibiting behaviors similar to those seen in humans under the influence of cocaine.

By successfully creating fruit flies that are addicted to cocaine, researchers can now study the mechanisms of addiction more effectively. This genetic model allows for the analysis of hundreds of genes simultaneously, enabling a faster and more comprehensive understanding of how cocaine addiction develops in the body.

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The ability to scale research quickly in fruit flies provides a unique opportunity to identify genes associated with addiction that may be challenging to uncover in more complex organisms. By studying these genetic targets, researchers can develop potential treatment options that could translate into therapies for human addiction.

In conclusion, the engineered fruit flies offer a powerful tool for studying addiction and developing targeted therapies for cocaine addiction. By unraveling the mechanisms of addiction in these insects, researchers can pave the way for innovative treatments that may ultimately benefit human patients struggling with substance abuse. This study highlights the importance of using genetic models like fruit flies to advance our understanding of addiction and explore new avenues for treatment. The world of online marketing is constantly evolving, and as a business owner, it’s important to stay up-to-date with the latest trends and strategies to effectively promote your products or services. One of the most popular and effective forms of online marketing today is social media marketing.

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TAGGED:AlteredcocainecraveFliesfruitgeneticallyResearchers
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