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American Focus > Blog > Tech and Science > Scientists Just Solved a 100-Million-Year-Old Mystery About Platypus Sex : ScienceAlert
Tech and Science

Scientists Just Solved a 100-Million-Year-Old Mystery About Platypus Sex : ScienceAlert

Last updated: June 15, 2025 8:30 am
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Scientists Just Solved a 100-Million-Year-Old Mystery About Platypus Sex : ScienceAlert
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Scientists have long been fascinated by the unique reproductive systems of Australia’s egg-laying mammals, the platypus and echidna. These creatures have puzzled researchers for decades with their unconventional genetic toolkit for developing male and female embryos. However, a recent study published in Genome Biology has shed light on this mystery, revealing that a single gene, similar to those found in fish and amphibians, plays a crucial role in determining sex in monotremes.

Monotremes, the most ancient group of mammals, have a distinct method of sex determination. While most mammals rely on the X and Y chromosomes to determine sex, monotremes have a complex system involving multiple X and Y chromosomes. The discovery of the anti-Muellerian hormone (AMH) gene on the Y chromosomes of platypuses and echidnas has provided valuable insight into this process.

Researchers have traced the evolution of the AMH gene in monotremes back to a pivotal event around 100 million years ago. Changes in the AMH gene allowed it to evolve into AMHY, the gene responsible for male sexual development in monotremes. Unlike other mammal sex determination genes, AMHY functions as a hormone, acting at the cellular level to regulate gene expression.

This groundbreaking research not only uncovers the mechanism behind sex determination in monotremes but also highlights the evolutionary significance of the AMH gene. The findings suggest that AMHY may be a key player in sex determination across various species, making it a unique example of hormone-driven sex determination in mammals.

Moving forward, researchers plan to delve deeper into the differences between AMHX and AMHY in monotremes compared to other mammals. By unraveling the intricacies of these genes, scientists hope to gain a better understanding of the evolutionary forces that have shaped the reproductive biology of these fascinating creatures.

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This article was co-authored by Linda Shearwin, Researcher at the University of Adelaide, and Frank Grützner, Professor at the School of Biological Sciences at the University of Adelaide. It was originally published on The Conversation under a Creative Commons license. For more information, you can access the original article here.

TAGGED:100MillionYearOldMysteryPlatypusScienceAlertScientistsSexSolved
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