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American Focus > Blog > Entertainment > ‘St. Denis Medical’ Season 2 Adds Five Guest Stars
Entertainment

‘St. Denis Medical’ Season 2 Adds Five Guest Stars

Last updated: October 30, 2025 5:45 pm
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‘St. Denis Medical’ Season 2 Adds Five Guest Stars
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St. Denis Medical is gearing up for an exciting Season 2 with a star-studded guest roster. According to Variety, Olympic gold medalist Adam Rippon is set to join the show alongside Paul Scheer, Wayne Knight, Jessica Lowe, and Jared Goldstein. These new additions will join previously announced guest stars for the NBC mockumentary series.

The upcoming season of “St. Denis Medical” will also feature Ariana Madix, Draymond Green, Kristen Schaal, Lauren Weedman, Frankie Quiñones, Lauren Lapkus, Tim Baltz, Jeremiah Brown, and Jonah Beckett. The series stars Wendi McLendon-Covey, David Alan Grier, Allison Tolman, Josh Lawson, Kahyun Kim, Mekki Leeper, and Kaliko Kauahi.

The highly anticipated Season 2 of “St. Denis Medical” is set to premiere on Nov. 3 with back-to-back episodes airing on NBC from 8-9 p.m. ET/PT. Viewers can catch new episodes streaming the following day on Peacock.

The logline for the new season teases, “After receiving a large private donation, hospital administrator Joyce (McLendon-Covey) bites off more than she can chew while her employees navigate staff shortages, office conflicts, and their own personal lives.”

Created by Eric Ledgin and Justin Spitzer, “St. Denis Medical” is led by showrunner and executive producer Eric Ledgin. Other executive producers include Spitzer, Simon Heuer, Ruben Fleischer, Bridget Kyle, and Vicky Luu. Universal Television is the studio behind the series.

In Season 2, Adam Rippon will portray a male patient trying to convince Bruce of his ailments, while Paul Scheer takes on the role of Ruben, a brother working with the St. Denis Medical doctors to save his sibling in need of a kidney transplant. Wayne Knight plays Dr. Axler, a cardiologist who clashes with Ron, and Jessica Lowe portrays Violet, a cheerful woman looking to win back her ex-husband at St. Denis. Jared Goldstein rounds out the cast as a technician operating a new health screening machine at the medical facility.

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Fans can look forward to the exciting new developments and guest appearances in the upcoming season of “St. Denis Medical.”

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