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American Focus > Blog > Tech and Science > Stomach Ulcer Bacteria Could Be a Surprise Ally Against Alzheimer’s : ScienceAlert
Tech and Science

Stomach Ulcer Bacteria Could Be a Surprise Ally Against Alzheimer’s : ScienceAlert

Last updated: June 18, 2025 6:55 am
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Stomach Ulcer Bacteria Could Be a Surprise Ally Against Alzheimer’s : ScienceAlert
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Alzheimer’s disease is a devastating condition that affects millions of people worldwide. Every three seconds, someone develops dementia, with Alzheimer’s disease accounting for 60% to 70% of all cases. While scientists have made progress in understanding the disease, there is still no cure due to its complex and multifaceted nature.

The disease is characterized by the accumulation of two proteins, amyloid-beta and tau, in the brain. Amyloid-beta forms sticky plaques on the outside of brain cells, disrupting communication between neurons. Tau accumulates inside brain cells, forming tangles that lead to cell death. These plaques and tangles are the hallmark features of Alzheimer’s disease, shaping research and treatment strategies for decades.

Recent research has uncovered a surprising discovery that a protein from Helicobacter pylori, a bacterium known for causing stomach ulcers, can block the toxic buildup of both amyloid-beta and tau. This finding opens up a new potential strategy for combating Alzheimer’s disease and other conditions driven by amyloid aggregation.

The study found that a fragment of the H. pylori protein called CagAN effectively reduced the formation of amyloid aggregates in both bacterial species and human amyloid-beta proteins. This protein fragment not only inhibited amyloid-beta aggregation but also blocked tau aggregation, suggesting a promising therapeutic avenue for Alzheimer’s disease and other amyloid-related conditions.

The research is still in its early stages, with experiments conducted in lab settings rather than in animals or humans. However, the findings offer hope for developing new treatments that target the underlying mechanisms of Alzheimer’s disease.

The discovery of the protective properties of the H. pylori protein fragment raises questions about the bacterium’s role in health and disease. While H. pylori infection has been linked to Alzheimer’s disease in some studies, the relationship is not fully understood. Future research may explore the potential beneficial effects of certain components of H. pylori and their impact on various health conditions.

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As medicine progresses towards precision and personalized approaches, understanding the intricate interactions between microbes and the human body becomes crucial. Instead of eradicating all bacteria with antibiotics, it may be more beneficial to identify and leverage the beneficial aspects of certain bacteria for therapeutic purposes.

In conclusion, the study on H. pylori protein fragment’s ability to block amyloid aggregation in Alzheimer’s disease opens up a new avenue for research and potential treatments. By harnessing the protective properties of bacterial proteins, we may uncover innovative strategies for combating neurodegenerative diseases and other conditions driven by amyloid accumulation.

TAGGED:AllyAlzheimersbacteriaScienceAlertstomachSurpriseUlcer
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