Intermittent fasting has gained popularity in recent years as a way to improve metabolism and promote weight loss. However, a new study conducted by researchers from the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) has found that certain forms of intermittent fasting may not have the expected impact on metabolic or cardiovascular health.
The study involved 31 overweight or obese women who were put on two different intermittent fasting schedules for two weeks each. The schedules, known as time-restricted eating (TRE), involved fasting for a specific period of time each day – either from 8 am to 4 pm or from 1 pm to 9 pm. Despite the different timing of the fasting schedules, the participants were allowed to eat normally and consume the same amount of total calories, making this an isocaloric study.
While the women did experience some weight loss during the study, other expected benefits such as lower blood sugar levels, blood pressure, and cholesterol did not materialize. The researchers suggested that the metabolic improvements seen in previous studies may be more related to calorie restriction rather than the timing of eating.
The study also revealed changes in the participants’ circadian rhythms, indicating that our internal clocks can be influenced by when we eat. This highlights the importance of paying attention to both the timing of meals and overall energy balance for those looking to improve their metabolism and lose weight.
Improving metabolic health is crucial for addressing conditions like insulin resistance and diabetes. The findings from this study may lead to a reevaluation of how diets are structured for individuals with these conditions or at risk of developing them.
Moving forward, the researchers plan to further investigate the relationship between calorie consumption, timing of eating, and metabolic health. They believe that timing may play a role in influencing biological markers of health, particularly in scenarios where calories are restricted.
While intermittent fasting continues to be a topic of interest for researchers, it’s important to consider the varying factors that can impact study results, such as diet composition, study duration, and participant characteristics. The researchers emphasize the need for future studies to explore the potential impact of eating timing under hypocaloric conditions and determine whether optimal timing varies among individuals.
This study was published in Science Translational Medicine. As research in this area continues to evolve, it is clear that further investigation is needed to fully understand the effects of intermittent fasting on metabolic and cardiovascular health.

