Healthcare has undergone a rapid transformation in recent years, moving from being considered a digital laggard to becoming one of the fastest-adopting sectors for domain-specific AI. The use of specialized AI tools in healthcare has increased sevenfold since 2024 and tenfold since 2023, with nearly a quarter of provider organizations now utilizing these technologies.
One significant driver of this adoption has been ambient AI medical scribes, which have received over $600 million in investment and accounted for nearly 45% of all inpatient and outpatient AI spending. These ambient scribes offer a clean ROI formula by reducing documentation burden, improving coding accuracy, and alleviating physician burnout. However, it is crucial to understand that while scribes assist in capturing conversations and formatting clinical documentation, they do not address the core bottleneck in healthcare: the moment when clinicians make decisions.
The real leverage in healthcare lies in influencing these decisions, which have significant clinical, economic, and operational implications. From prescribing medication to ordering tests, a physician’s decisions impact not only a patient’s clinical outcome but also the overall cost, revenue, and risk exposure within the healthcare ecosystem.
The history of influencing physicians in healthcare dates back decades, from pharmaceutical detailing to algorithmic nudges. Pharmaceutical companies have spent billions on sales reps and sponsored content to shape prescribing habits, while digital tools like UpToDate have revolutionized clinical decision making by providing evidence-based reference materials. The rise of AI-driven clinical decision support (CDS) is the next frontier, combining the immediacy of EHR nudges with the authority of evidence-based references and the personalization of real-world patient data.
In the competitive landscape of AI-driven CDS, several structural moats have emerged, including real-world data scale, curated expert content, network effects, workflow control, pharma monetization power, and the convergence of ambient documentation and CDS. These moats define the competitive frontier of CDS, with data, trust, access, workflows, revenue models, and contextual insights playing crucial roles in shaping clinician behavior.
As healthcare moves towards a future where AI influences clinical decisions, organizations with defensible moats will have the privilege of shaping the rules of clinical practice. The integration of AI-driven CDS into healthcare systems will not only remove administrative burden but also significantly impact economics, outcomes, and power within the industry.
This shift towards shaping decisions in healthcare underscores the importance of building and defending competitive moats that go beyond engineering sophistication. Proprietary data, editorial authority, workflow ownership, network distribution, and monetization advantages will be key factors in determining the success of organizations in the evolving landscape of AI-driven healthcare.

