Obesity and Low Choline Levels Linked to Accelerated Brain Aging, Study Finds
A recent study has shed light on a potential connection between obesity and low levels of the essential nutrient choline, suggesting that this combination could contribute to accelerated brain aging and early signs of neurodegenerative diseases such as Alzheimer’s. Led by researchers from Arizona State University (ASU), the study highlights the importance of maintaining adequate choline levels for optimal cognitive health.
Choline is known to play a crucial role in maintaining overall health, and its deficiency, coupled with the metabolic stresses associated with obesity, may serve as early indicators of cognitive decline even before symptoms manifest, according to the findings. Neurobiologist Ramon Velazquez from ASU emphasizes the significance of choline as a marker of metabolic and brain dysfunction, underscoring the importance of adequate daily intake for human health.
The study recruited 15 individuals with obesity and 15 healthy controls, analyzing key chemical levels and biomarkers in their systems. The results revealed notable differences in individuals with obesity, including lower choline levels, increased inflammation biomarkers, and elevated levels of neurofilament light (NfL) â a protein associated with neuron damage.
Furthermore, a strong correlation was observed between reduced choline and higher NfL levels in obese individuals, mirroring similar patterns found in post-mortem brain tissue from individuals with Alzheimer’s or mild cognitive impairment. While the study does not establish causation, it suggests a potential link between obesity, choline deficiency, and accelerated brain aging leading to dementia.
ASU behavioral neuroscientist Jessica Judd asserts that maintaining good metabolic health and adequate choline levels in young adults can contribute to neuronal health and set the foundation for healthy aging. The complexity of factors influencing brain aging and dementia underscores the need for further research to unravel the intricate relationship between obesity, choline, and neurodegeneration.
While the study highlights the role of choline in brain health, it also emphasizes the importance of incorporating choline-rich foods such as eggs, fish, poultry, beans, and vegetables into one’s diet to support overall well-being. Biochemist Wendy Winslow from ASU encourages individuals to prioritize choline intake to reduce inflammation and support their bodies and brains as they age.
Published in Aging and Disease, this study underscores the significance of maintaining adequate choline levels and addressing obesity as potential risk factors for cognitive decline and neurodegenerative diseases. By understanding and addressing these factors early on, individuals may mitigate the risk of developing conditions such as Alzheimer’s and promote healthy brain aging.
