By the constitutional authority granted to me as President of the United States, I hereby issue the following order:
Section 1. Purpose and Policy. This Administration is resolutely focused on advancing innovative strategies to prevent and treat illnesses affecting our children, with a significant emphasis on the role of artificial intelligence (AI). The unsettling reality is that pediatric cancer is the foremost cause of disease-related mortality among children aged 1 to 19 years in the U.S., with its incidence surging over 40% since 1975.
As I conveyed during my address to Congress this past March, reversing this alarming trend is a cornerstone objective for the Make America Healthy Again (MAHA) Commission, which was established under Executive Order 14212 on February 13, 2025. Harnessing the capabilities of AI is pivotal to swiftly achieve this goal.
In 2019, we initiated the Childhood Cancer Data Initiative (CCDI), committing $50 million annually for a decade to amplify research in this field. This effort aims to systematically collect, analyze, and generate crucial childhood cancer data. The CCDI is laying the groundwork for a robust data infrastructure that will facilitate groundbreaking discoveries.
By leveraging AI, we can enhance this initiative to derive impactful solutions for pediatric, adolescent, and young adult cancers. This transformative potential of AI could revolutionize our existing healthcare and research frameworks by utilizing rich, multimodal data—safeguarded with stringent privacy measures—to foster early diagnostics, identify effective treatments, and advance medical practices that promise to save lives.
Historically, families faced with the harrowing challenges of childhood cancer have often been let down by healthcare systems, which are slow to embrace advancements. We must now pivot towards prioritizing investments in AI-driven scientific endeavors, constructing unparalleled scientific datasets, and equipping researchers and clinicians with essential tools to convert data insights into enhanced care outcomes.
Sec. 2. Harnessing American AI Innovation. The MAHA Commission shall collaborate with the Secretary of Health and Human Services, the Assistant to the President for Science and Technology, and the Special Advisor for AI and Crypto. Together, we will implement the America’s AI Action Plan to explore innovative methodologies for leveraging advanced technologies like AI to improve diagnoses, treatments, cures, and preventive measures for pediatric cancer. Our initial focus will be on enhancing AI-driven solutions within the CCDI, particularly through:
(a) consolidating a multi-source data infrastructure for AI optimization and enhancing participant selection for clinical trials;
(b) employing AI tools to elevate the analysis of intricate biological systems, thus improving predictive models related to patient responses, disease progression, treatment side effects, while also transforming multi-omics and imaging data into novel diagnostic and therapeutic markers; and
(c) refining the design and execution of clinical trials by integrating multimodal data and optimizing AI applications to enhance trial accessibility, recruitment, management, and data interpretation.
Sec. 3. Increasing Investment and Engagement in Pediatric Cancer Research and Care Infrastructure. In conjunction with the Secretary, the Director of the Office of Management and Budget, the Director of the National Institutes of Health, and the Assistant to the President for Science and Technology, the MAHA Commission will prioritize the enhancement of pediatric cancer research and care by identifying strategies that include:
(a) escalating federal funding for the CCDI and related initiatives targeting pediatric cancer;
(b) motivating the private sector to employ the most advanced technologies, especially AI, to unlock cures for pediatric cancer.
Sec. 4. Improving Data Sharing and Empowering Patients. The Secretary, with guidance from the Assistant to the President for Science and Technology, will ensure that AI innovations are harmonized within current interoperability efforts. This aims to enhance the utility of electronic health records and claims data for both academic research and clinical trial design while granting patients and their families control over their health information. Additionally, the Secretary will establish interoperability standards for patient data that wisely accommodate structured and unstructured data and facilitate secure, privacy-compliant data exchanges.
Sec. 5. Definition. For the purposes of this order, “artificial intelligence” or “AI” shall be defined according to 15 U.S.C. 9401(3).
Sec. 6. General Provisions. (a) This order does not alter or affect:
(i) the authority granted by law to any executive department, agency, or its head;
(ii) the responsibilities of the Director of the Office of Management and Budget concerning budgetary, administrative, or legislative affairs.
(b) Implementation of this order will adhere to applicable laws and the availability of appropriations.
(c) This order does not confer any rights or benefits liable to be enforced by any party against the United States, its departments, agencies, or entities, or any other individual.
(d) The financial burden of publishing this order will fall upon the Department of Health and Human Services.
DONALD J. TRUMP
THE WHITE HOUSE,
September 30, 2025.
