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American Focus > Blog > Lifestyle > Need a Brain Boost? Lion’s Mane May Be the Answer
Lifestyle

Need a Brain Boost? Lion’s Mane May Be the Answer

Last updated: September 30, 2025 9:38 pm
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Need a Brain Boost? Lion’s Mane May Be the Answer
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All products featured on Vogue are independently selected by our editors. However, we may receive compensation from retailers and/or from purchases of products through these links.

In our fast-paced world, it feels like our minds are perpetually racing, causing a noticeable decline in our ability to focus. One possible solution? A powerhouse fungus known as lion’s mane. The science is compelling: high-quality lion’s mane supplements offer numerous benefits, including enhanced cognitive function, improved mood, stress relief, and support for the immune system.

“Lion’s mane is categorized as a nervine—an herb beneficial for the nervous system—and a nootropic, which aids in enhancing memory, focus, and concentration,” explains herbalist Rachelle Robinett, RH, AHG. “These functional mushrooms offer a plethora of advantages for not just gut health, but also brain health and overall immunity.” Not only does lion’s mane contribute to mental clarity and acute focus, but it also presents fewer of the common side effects linked to stimulants, such as jitters or energy crashes. It aids in stabilizing the hypothalamic-pituitary-adrenal (HPA) axis, fostering sustained energy levels, resilience to stress, and antioxidant defense. “Essentially, nervines like lion’s mane can offer quick alleviation of symptoms of anxiety that afflict countless individuals,” Robinett shares. “They are pivotal in helping restore our body’s abilities to respond to daily challenges in a constructive manner.”

Vogue’s Top Picks for Lion’s Mane Supplements

Selected in This Article



Best for Beginners

Atlas Coffee Club Atlas+ Coffee Superblend

Read our review

The advantages of incorporating lion’s mane into your routine are plentiful. However, for those just starting their journey with mushrooms, there are a few important things to keep in mind. “Lion’s mane isn’t a quick-fix solution,” points out Blaire Edwards-Maschotta, an herbalist and formulator with French skincare company Verdoie. “To reap its benefits, consistency over time is key; don’t expect results akin to that of coffee or an energy drink.” To help you embark on your lion’s mane journey, we’ve consulted leading herbalists about the myriad benefits, along with the six best lion’s mane supplements available.

In This Article:

  • What is lion’s mane?
  • What are the benefits of taking lion’s mane?
  • Do lion’s mane supplements actually work?
  • Is there a downside to taking lion’s mane?
  • Meet the Experts

Best Overall: Urban Moonshine Wonder Human

Urban Moonshine

Wonder Human

  • Why We Love It: These capsules are certified gluten-free, organic, and vegan, featuring a potent blend that includes lion’s mane, maitake, and reishi mushrooms. They are designed for long-term cognitive support while also providing a calming effect, keeping you focused and energized throughout your day. “Wonder Human uniquely blends supportive ingredients—like lion’s mane for cognitive enhancement and rhodiola for acute energy.” Edwards-Maschotta shares her experiences with Urban Moonshine, emphasizing their commitment to ethical sourcing practices. This supplement is particularly beneficial for those feeling overwhelmed or exhausted. “Lion’s mane should be viewed not just as a cognitive enhancer, but as a nourishing supplement with long-lasting benefits,” she advises.
  • Key Ingredients: Lion’s mane, maitake, reishi, dandelion root
  • Form: Capsules
  • Serving Size: 2 capsules
  • Certifications: USDA organic, cGMP compliant
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Best Mushroom Coffee: Atlas+ Coffee Superblend

Atlas Coffee Club

Atlas+ Coffee Superblend

  • Why We Love It: Edwards-Maschotta raves about this mushroom coffee, which is not only a flavorful beverage option but also infused with functional mushrooms and herbs that aid focus, clarity, and even support skin, energy, immunity, and gut health. It contains 45mg of caffeine, so coffee enthusiasts won’t feel deprived. “Each serving packs 1,000mg of lion’s mane alongside other beneficial ingredients,” Edwards-Maschotta states. A perfect beginner’s option, this coffee can seamlessly replace your regular caffeine fix, making it an easy introduction to the world of mushrooms without the usual harsh mushroom flavor that many dislike.
  • Key Ingredients: Lion’s mane, reishi, vitamin B12, vitamin D3, probiotics
  • Form: Powder-to-liquid
  • Serving Size: 1 tablespoon
  • Certifications: USDA Organic, third-party tested

Best Tasting: Alice Mushrooms Brainstorm

Alice

Mushrooms Brainstorm

  • Why We Love It: For those with a penchant for sweets, these delightful dark chocolate squares can satisfy your cravings while offering health benefits. Perfect as a pre-dinner or mid-morning treat, these chocolates contain less than a gram of sugar. They are made from mushrooms sourced from women-owned farms, utilizing traditional growing methods (e.g., lion’s mane grown on oak and maple logs). Furthermore, they use the nutrient-dense fruiting bodies of the mushrooms, which are believed to provide enhanced health benefits. “When selecting lion’s mane products, it’s essential to ensure they are from the fruiting body, as it contains more bioactive compounds necessary for cognitive and immune support,” Edwards-Maschotta explains.
  • Key Ingredients: Organic semi-sweet dark chocolate, lion’s mane, cordyceps
  • Form: Chocolate square
  • Serving Size: 1 square
  • Certifications: USDA organic, OU-D kosher certified, third-party tested

Best Powder: Moon Juice Brain Dust

  • Why We Love It: Eliminate brain fog with this adaptogenic mushroom powder, designed to blend effortlessly into beverages without clumping or chalkiness. Offering a malty, mildly bitter flavor, this mixture of nootropics is great for steering clear of afternoon slumps or enhancing focus during important tasks. “Lion’s mane is beneficial for both preventative and remedial use,” Robinett notes. “Integrate it into your self-care practices, consume it during stressful times, or even as a part of your nightly routine.”
  • Key Ingredients: Lion’s mane, ginkgo, rhodiola, ashwagandha
  • Form: Powder
  • Serving Size: 1 teaspoon
  • Certifications: GMP-certified, third-party tested
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Best Liquid: MaryRuth Organics Lion’s Mane Mushroom Supplement

MaryRuth Organics

Lion’s Mane Mushroom Supplement

  • Why We Love It: For a quick, easily digestible dose, the MaryRuth Organics mushroom supplement features 100% organic lion’s mane that you can place directly on your tongue or add to beverages. With 1,180 mg of lion’s mane per serving—up to three times a day—it simplifies getting an effective dosage. As Edwards-Maschotta points out, “Effective doses for cognitive enhancement typically start at around 2,000 mg/day, so this supplement ensures adequate strength without unnecessary strain.”
  • Form: Drops
  • Serving Size: 1 mL
  • Certifications: USDA organic, Non-GMO Project verified, B Corp certified, Clean Label Project certified

Best Gummy: Grüns Nutrops Lion’s Mane Gummy

Grüns

Nütrops Sugar-Free Lion’s Mane Gummy

  • Why We Love It: These gummies come with a delicious lemon meringue flavor while also being caffeine-free and suitable for a variety of diets—they’re vegan, gluten-free, nut-free, and dairy-free! Conveniently packaged in individual servings, they provide a mental uplift whenever you need it. “Efforts are best realized with regular usage of lion’s mane,” Robinett confirms, noting that consistent daily intake yields the best results. Each packet contains 10,000mg of multiple adaptogenic mushrooms to help promote energy, clarity, and memory.
  • Key Ingredients: Lion’s mane, chaga, reishi, maitake, cordyceps
  • Form: Gummy
  • Serving Size: 1 packet
  • Certifications: NSF-certified, GMP compliant, third-party tested

Everything You Need To Know

Lion’s mane refers to a type of edible and medicinal mushroom from several Hericium species, commonly represented by Hericium erinaceus. Edwards-Maschotta elaborates that the name “Hericium” translates to “hedgehog” due to its spiky appearance. This powerful mushroom flourishes in North America and Eurasia. It has culinary applications in places like France, Japan, and China, while also being utilized medicinally by Native American cultures.

Interestingly, lion’s mane can be consumed in numerous formats, including powders, tinctures, capsules, or even grilled as a meat substitute. “The existence of a mushroom that aids in nerve regeneration and cognitive enhancement is astonishing, showcasing the expansive potential of herbalism,” adds Robinett.

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What are the benefits of lion’s mane?

According to Robinett, those eager to improve their cognitive health—memory, focus, and concentration—will find value in lion’s mane. Additionally, it has been used extensively across cultures for its numerous benefits. “Known primarily for its positive effects on the cognitive and nervous systems, it has also served traditional medicine practitioners as a digestive aid,” Edwards-Maschotta notes.

As research indicates, lion’s mane possesses antioxidant and antimicrobial properties, and there’s increasing interest surrounding its neuroprotective effects. Edwards-Maschotta explains, “Research shows potential for enhances in nerve-growth factor synthesis and research studies indicate cognitive support, especially with consistent usage.” While further research is needed, the findings thus far are encouraging.

Do lion’s mane supplements actually work?

While lion’s mane herbal supplements can be effective, results won’t appear overnight. “Regular daily intake is essential for noticeable benefits,” says Edwards-Maschotta. Current studies on mushrooms as medicine, particularly lion’s mane, are revealing exciting potential in both acute and long-term health enhancements among healthy individuals. “Historically, most studies involved older adults with cognitive decline, making recent findings emphasizing healthy young adults quite significant,” she observes. Although it involves a relatively small sample size, one recent study indicated both immediate cognitive enhancements and long-term improvements in self-reported stress levels.

Is there a downside to lion’s mane supplementation?

As with any food or supplement, possible allergies or reactions may arise. Always consult with a healthcare professional before commencing any supplement regimen. If you have a known mushroom allergy, it’s crucial to avoid lion’s mane. Besides those concerns, there are minimal negatives, with no significant contraindications or side effects reported, other than the necessity for consistent use to maximize advantages.

Contents
Vogue’s Top Picks for Lion’s Mane SupplementsSelected in This ArticleIn This Article:Best Overall: Urban Moonshine Wonder HumanBest Mushroom Coffee: Atlas+ Coffee SuperblendBest Tasting: Alice Mushrooms BrainstormBest Powder: Moon Juice Brain DustBest Liquid: MaryRuth Organics Lion’s Mane Mushroom SupplementBest Gummy: Grüns Nutrops Lion’s Mane GummyEverything You Need To Know

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