Respiratory syncytial virus (RSV) is often mistaken for a common cold, but recent studies have shown that it can be just as severe as other well-known respiratory viral infections like influenza and COVID-19. Researchers from Singapore General Hospital (SGH) working under the Program for Research in Epidemic Preparedness And REsponse (PREPARE) conducted three large-cohort studies to assess the severity of RSV and its impact on patients.
In the first study, published in The Lancet Regional Health – Western Pacific, close to 13,000 adult hospitalizations for RSV, COVID-19, and influenza were compared in terms of 28-day mortality and intensive care unit admission rates. It was found that RSV hospitalizations had higher death rates and more ICU admissions compared to influenza, indicating the severity of the illness.
The second study, published in JAMA Network Open, focused on the risk of acute cardiac complications in patients hospitalized for RSV, COVID-19, and influenza. The results showed that RSV hospitalizations had a significantly higher risk of cardiovascular events compared to COVID-19 and vaccine-breakthrough influenza hospitalizations.
The third study, published in Clinical Microbiology and Infection, looked at long-term complications following RSV infection in adults and children. It was found that adults hospitalized for RSV had an increased risk of cardiovascular and neurological complications up to 300 days post-hospitalization. Pediatric RSV hospitalizations also showed a higher risk of respiratory complications compared to COVID-19 and influenza.
RSV is a respiratory virus that causes symptoms similar to the flu, such as runny nose and sore throat. It spreads through close contact, respiratory droplets, or contaminated surfaces. While most people experience mild symptoms, young children, older adults, and those with underlying health conditions are at higher risk of severe RSV.
Dr. Ian Wee, a Consultant at SGH, emphasized the importance of understanding the severity of RSV, especially in at-risk populations. He recommended practicing good hygiene, staying home when sick, and discussing RSV protection with healthcare providers.
Overall, the studies highlight the need for more research on RSV and the importance of recognizing its potential severity. By raising awareness and taking preventive measures, individuals can protect themselves and others from the impact of respiratory viral infections like RSV.

