The study published in JAMA Network Open sheds light on the importance of timely vaccinations in childhood and the potential consequences of delays in the vaccination schedule. According to the study, babies who miss their first round of vaccines at 2 months of age are significantly less likely to receive the measles, mumps, and rubella (MMR) vaccine by the age of 2. This finding underscores the critical role pediatricians play in educating and persuading parents to follow the recommended vaccination schedule for their children.
Nina Masters, the lead author of the study and an epidemiologist, emphasized the long-term implications of early vaccination delays leading to subsequent delays or missed vaccinations. The data revealed a concerning trend of decreased MMR vaccine coverage, with a notable increase in children not receiving their first MMR shot by age 2. This trend is particularly alarming in light of the recent surge in measles cases in the United States, with 2025 marking the highest number of confirmed cases in over three decades.
The study analyzed electronic health records data from Truveta, a health care data analytics company, encompassing approximately 120 million individuals across the country. By examining vaccination patterns in over 300,000 children born between 2017 and 2023, the researchers identified a clear link between early vaccine delays and subsequent vaccination patterns.
Notably, the study highlighted the critical role of pediatricians in influencing parents’ decisions regarding vaccinations. Early communication and education about the importance of timely vaccinations, starting before the 2-month appointment, were identified as crucial factors in ensuring compliance with the recommended schedule. The American Academy of Pediatrics advocates for frequent interactions between pediatricians and infants in the early stages of life to reinforce the importance of vaccinations.
The findings underscore the need for proactive measures to address vaccine hesitancy and ensure high vaccination coverage rates among children. With measles outbreaks on the rise, it is essential for healthcare providers to engage with parents early on and provide clear, evidence-based recommendations on childhood vaccinations. By addressing delays in the vaccination schedule and promoting timely immunizations, healthcare professionals can help safeguard children against preventable diseases and maintain public health initiatives.
When it comes to vaccinating children, studies have shown that receiving a recommendation from a trusted medical practitioner is key in persuading parents to follow through. However, the timing of these recommendations can be crucial, especially with multiple shots scheduled for the 2-month visit. According to experts, pediatricians must focus on building trust, educating parents, and discussing vaccines early on to avoid potential delays or refusals.
A recent study highlighted the challenge of ensuring that babies adhere to the recommended vaccination schedule. It found that less than half of the babies within the cohort studied were seeing their medical providers as per the American Academy of Pediatrics (AAP) schedule. This was despite the fact that these babies had a medical home and access to health insurance. The numbers are likely even lower for children without insurance or a pediatric practice to visit regularly.
Dr. Brewer emphasized that while most children do receive some vaccines, deviations from the recommended schedule can be a red flag. Parents who skip one vaccine are more likely to skip others, indicating a potential trend towards vaccine hesitancy. Only a small percentage of people completely refuse all vaccines, but those who delay or skip certain shots may be less likely to fully vaccinate their children.
The study did not account for the impact of recent changes in vaccination policy, including the decision to revise the recommendation for hepatitis B vaccination at birth. The CDC’s vaccine advisory committee now suggests offering the vaccine to newborns only if their mothers tested positive for hepatitis B or if their status is unknown. Otherwise, babies can start the hepatitis B vaccination at 2 months of age, based on parental preference.
Looking ahead, researchers are considering examining the implications of these changes to better understand how they may affect vaccination rates and parental decisions. By staying informed and proactive, healthcare providers can continue to advocate for timely and comprehensive vaccination practices to protect children from preventable diseases.

