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American Focus > Blog > Entertainment > Brilliant Minds Returns in May With Guests Mamie Gummer, Ed Begley Jr.
Entertainment

Brilliant Minds Returns in May With Guests Mamie Gummer, Ed Begley Jr.

Last updated: March 14, 2026 12:00 am
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Brilliant Minds Returns in May With Guests Mamie Gummer, Ed Begley Jr.
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NBC’s “Brilliant Minds” is set to return for its final six episodes of Season 2 in May, with a star-studded lineup of guest stars joining the cast. Ed Begley Jr., Anne Archer, Mamie Gummer, and Ana Ortiz are set to make appearances on the show, adding new layers of complexity to the already gripping storyline.

Begley Jr. will take on the role of Duke in Episode 220, playing a once-commanding patriarch who struggles to hold onto his defining memories. Archer will portray Bonnie, a kindhearted matriarch facing the challenge of reconciling her dream future with the harsh realities of the present. Gummer will guest star as Regan in Episode 217, a psychiatric patient whose mysterious case intrigues Dr. Wolf, played by Zachary Quinto. And in Episode 218, Ortiz will play Alyssa Rivera, a recently released ex-convict determined to reclaim her old life.

The show, inspired by author and neurologist Oliver Sacks, follows Dr. Wolf as he unravels medical mysteries of the mind at Bronx General. Quinto leads the ensemble cast, which includes Tamberla Perry, Ashleigh LaThrop, Alex MacNicoll, and more.

Created by Michael Grassi, “Brilliant Minds” boasts an impressive lineup of executive producers, including Greg Berlanti and Andy Serkis. The show is a collaboration between Warner Bros. Television and Universal Television, promising a blend of drama, mystery, and medical intrigue.

With its star-studded guest lineup and compelling storyline, “Brilliant Minds” is poised to captivate audiences once again as it returns for its final episodes of Season 2. Don’t miss the action when the show airs on Wednesday, May 27th at 8 p.m. ET on NBC.

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