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Tech and Science

Can we genetically improve humans using George Church’s famous list?

Last updated: January 30, 2026 2:15 pm
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Can we genetically improve humans using George Church’s famous list?
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Genetic Enhancement: Separating Science Fiction from Reality

Genetic enhancement has long been a topic of fascination in science fiction, with visions of superhumans with enhanced abilities captivating our imagination. But could this futuristic concept become a reality? A recent start-up called Bootstrap Bio is openly aiming to offer would-be parents the chance to genetically enhance their children. The founder of Bootstrap Bio believes that genetics shouldn’t be a lottery and that everyone should have the opportunity to choose their genes for themselves and their descendants.

To explore the possibilities of genetic enhancement, biologist George Church at Harvard University maintains a list of “protective and enhancing” gene variants. This list contains over 100 items, with mutations that range from protecting against diseases to reducing aggression. However, not all traits on the list are desirable. For example, one gene mutation could potentially give a person six fingers on each hand, while two gene deletions result in insensitivity to pain – a trait that can lead to severe injuries.

While some traits on the list may seem appealing, such as living longer or having higher intelligence, the reality of genetic enhancement is far more complex. There are trade-offs to consider, as some gene variants may have unintended consequences, such as an increased risk of certain diseases. Additionally, our understanding of genetic variants is still in its infancy, making it challenging to predict the full effects of genetic engineering.

Furthermore, the idea of heritable genome editing raises ethical concerns and safety issues. While genetic enhancement may seem like a way to level the playing field, the focus should instead be on addressing existing inequalities in access to healthcare, education, and nutrition. Rather than trying to boost the genes of a select few, efforts should be directed towards ensuring that all children have the opportunity to reach their genetic potential.

In conclusion, while the concept of genetic enhancement is intriguing, the reality is far more nuanced. Before we can seriously consider genetic engineering, we need to expand research efforts to better understand the implications of gene variants. Genetic enhancement may offer potential benefits, but it is essential to proceed with caution and prioritize addressing existing disparities in society.

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