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American Focus > Blog > Tech and Science > Common Supplement Shows a Concerning Link to Heart Failure : ScienceAlert
Tech and Science

Common Supplement Shows a Concerning Link to Heart Failure : ScienceAlert

Last updated: March 3, 2026 5:20 am
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Common Supplement Shows a Concerning Link to Heart Failure : ScienceAlert
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Research into the long-term usage of melatonin as a sleeping aid has raised concerns among scientists. A recent analysis of adults with insomnia has found that individuals prescribed melatonin for more than a year may be at a higher risk of heart issues. The study, which has not yet been peer-reviewed, looked at over 130,000 adults across multiple countries.

The findings revealed that those who used melatonin long-term had an 89 percent higher risk of heart failure over a five-year period and were twice as likely to die from any cause compared to those not using melatonin. While these results are preliminary and do not change current health recommendations, they do highlight the need for further research into the safety of prolonged melatonin use.

Melatonin is one of the most popular natural products taken by adults in the US, but there is limited research on its effects after short-term use. Most studies suggest that melatonin is safe and well-tolerated for around 1 to 2 months, but the potential risks of long-term use need to be better understood as the supplement’s popularity grows.

The research was presented at the American Heart Association’s Scientific Sessions, where medical scientist Ekenedilichukwu Nnadi cautioned that melatonin supplements may not be as harmless as commonly assumed. While some studies suggest that long-term melatonin use is safe, comprehensive research is lacking, and more studies are needed to clarify its safety profile.

It is important to note that melatonin supplements are available over the counter in the US and many other countries, allowing patients to take them without medical guidance. While some studies suggest that long-term melatonin use is safe, the recent analysis found that those who took melatonin for over a year were almost 3.5 times as likely to be hospitalized for heart failure and had an increased risk of dying from any cause.

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Despite the concerning findings, the study’s methodology has limitations, as participants were not surveyed on their melatonin use. This means that the control group may have included individuals who took melatonin without a prescription. Experts caution that while the research raises important questions about the safety of long-term melatonin use, more studies are needed to confirm these associations.

In conclusion, while melatonin may be a popular sleeping aid, the potential risks of long-term usage should not be overlooked. More research is needed to understand the safety profile of melatonin, especially as its popularity continues to rise. It is essential for healthcare providers to counsel patients about the potential risks of prolonged melatonin use and to monitor its effects closely.

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