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American Focus > Blog > Health and Wellness > First Pill For Obstructive Sleep Apnea Shows Promise In Phase 3 Study
Health and Wellness

First Pill For Obstructive Sleep Apnea Shows Promise In Phase 3 Study

Last updated: June 29, 2025 8:12 pm
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First Pill For Obstructive Sleep Apnea Shows Promise In Phase 3 Study
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The American Academy of Sleep Medicine has reported that approximately 26 percent of adults between the ages of 30 and 70 years suffer from obstructive sleep apnea (OSA). This condition, characterized by repeated pauses in breathing during sleep due to relaxed throat muscles obstructing the airway, can have serious consequences if left untreated. OSA can lead to sleep deprivation, daytime drowsiness, and an increased risk of chronic medical conditions such as high blood pressure, heart disease, and stroke.

Currently, treatment options for OSA focus on keeping the airway open to allow for uninterrupted breathing during sleep. These options include changes in sleep position, CPAP masks and machines that provide continuous positive airway pressure, mouthpieces that help keep the throat open, and in severe cases, surgical interventions. Weight loss can also be beneficial for those with OSA caused by obesity, as excess fatty tissue in the neck can contribute to airway blockage.

Recently, Apnimed, Inc. announced promising results from the SynAIRgy phase 3 clinical trial of their AD109 pill, a potential new treatment for OSA. The pill, a combination of aroxybutynin and atomoxetine, works to increase nerve signals that control the muscles in the upper airway, ultimately reducing the severity of OSA. Participants in the trial experienced significant reductions in their apnea-hypopnea index (AHI), a measure of OSA severity, with over half achieving a reduction in disease severity and a quarter achieving complete control of their OSA.

The positive results from the SynAIRgy trial have paved the way for Apnimed to submit a New Drug Application for AD109 to the FDA by early 2026. If approved, AD109 would be the first prescription pill specifically designed for obstructive sleep apnea, offering a new treatment option for the millions of adults in the U.S. who suffer from this condition. With the potential for improved treatment outcomes and increased comfort for OSA patients, AD109 represents a significant advancement in the management of this prevalent sleep disorder.

See also  SUVs pose greater risk of death or serious injury to pedestrians and cyclists, study shows
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