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American Focus > Blog > Sports > Indianapolis Colts vs. San Francisco 49ers projected starting lineup and depth chart for Week 16 MNF
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Indianapolis Colts vs. San Francisco 49ers projected starting lineup and depth chart for Week 16 MNF

Last updated: December 22, 2025 11:50 am
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Indianapolis Colts vs. San Francisco 49ers projected starting lineup and depth chart for Week 16 MNF
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The upcoming Week 16 game between the Indianapolis Colts and the San Francisco 49ers is set to be a thrilling matchup between two teams heading in different directions. The Colts are looking to snap a four-game losing streak, while the 49ers are riding a hot streak and aiming to secure the top seed in the NFC.

Despite their injuries on both sides of the ball, the 49ers have managed to stay in contention for the No. 1 seed in the NFC. Coach Kyle Shanahan’s team has shown resilience and determination, and winning their remaining games could see them achieve this remarkable feat.

On the other hand, the Colts started the season strong but have faltered in recent weeks, losing four consecutive games. With their playoff hopes hanging by a thread, they will need to turn things around quickly to stay in the postseason race.

Philip Rivers will continue to lead the Colts as their starting quarterback, filling in for the injured Daniel Jones. Rivers made a solid return last week and will be looking to build on that performance against the 49ers.

Here is a breakdown of the projected starting lineups for both teams in their crucial Week 16 matchup:

Indianapolis Colts projected starting lineup:

  • QB: Philip Rivers
  • RB: Jonathan Taylor
  • WR: Michael Pittman Jr.
  • WR: Alec Pierce
  • WR: Josh Downs
  • TE: Tyler Warren
  • LT: Luke Tenuta
  • LG: Quenton Nelson
  • C: Tanor Bortolini
  • RG: Matt Goncalves
  • RT: Jalen Travis

    San Francisco 49ers projected starting lineup:

  • QB: Brock Purdy
  • RB: Christian McCaffrey
  • WR: Jauan Jennings
  • WR: Kendrick Bourne
  • WR: Demarcus Robinson
  • TE: George Kittle
  • FB: Kyle Juszczyk
  • LT: Trent Williams
  • LG: Spencer Burford
  • C: Jake Brendel
  • RG: Dominick Puni
  • RT: Colton McKivitz

    The depth charts for both teams reveal the depth and talent on each roster, with key players stepping up in the absence of injured starters. The special teams units for both the Colts and the 49ers are also ready to make an impact in the game.

    For fans looking to watch the Colts vs. 49ers game, it will be broadcast on ESPN and ABC, with Joe Buck, Troy Aikman, Lisa Salters, and Laura Rutledge providing commentary. Live streaming options include FuboTV and ESPN+.

    As the two teams prepare to face off on Monday night, the stakes are high for both sides. The Colts will be looking to turn their season around, while the 49ers aim to continue their impressive run towards securing the top seed in the NFC. It promises to be an exciting and competitive matchup at Lucas Oil Stadium.

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TAGGED:49ersChartColtsdepthFranciscoIndianapolisLineupMNFprojectedSanStartingWeek
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