Researchers have discovered a unique use for a mosquito’s proboscis – the long, thin structure that pierces the skin. In a study published in Science Advances, mechanical engineer Changhong Cao and his team explored the potential of using the proboscis as a nozzle for 3-D printing, a technique they refer to as “3-D necroprinting.”
The field of necrobotics, which involves incorporating animal parts into high-tech machines, inspired the researchers to explore the proboscis as a printing nozzle. By utilizing the unique geometry and mechanics of the mosquito proboscis, they were able to achieve intricate 3-D printing with lines as fine as 20 micrometers. This level of precision opens up new possibilities for advanced microengineering.
Daniel Preston, a mechanical engineer at Rice University, commended the use of natural parts in 3-D printing, highlighting how it can lower costs and eliminate barriers to entry in the field. By leveraging parts that nature has already perfected, researchers can democratize the 3-D printing process and enhance sustainability in manufacturing.
After analyzing various biological structures like stingers, fangs, and harpoons, the researchers settled on the female Aedes aegypti mosquito’s proboscis for its straight shape, small inner diameter, and durability under pressure. The team designed a specialized 3-D printer around the proboscis, coating it with 3-D resin for stability and connecting it to an engineered tip to facilitate ink flow.
To showcase the capabilities of the necrobotic tip, the researchers successfully printed intricate structures like a honeycomb shape, a maple leaf outline, and a scaffold for holding biological cell samples using commercially available bioink. Compared to conventional dispense tips with larger inner diameters, the mosquito proboscis nozzle demonstrated superior performance in achieving finer details.
Looking ahead, coauthor Jianyu Li envisions leveraging the mosquito proboscis in biomedical applications, particularly for drug delivery solutions using the proboscis as a microneedle. The potential of incorporating biotic materials in 3-D printing processes holds promise for unlocking new capabilities and advancing sustainability in microengineering.
In conclusion, the innovative use of the mosquito proboscis as a nozzle for 3-D printing represents a groundbreaking approach that merges nature-inspired design with cutting-edge technology. This research paves the way for future advancements in precision manufacturing and biomedical applications, showcasing the power of bioinspired solutions in engineering.

