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American Focus > Blog > World News > Murdoch Children’s Research Institute leads AI and stem cell tech
World News

Murdoch Children’s Research Institute leads AI and stem cell tech

Last updated: November 8, 2024 3:59 am
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Murdoch Children’s Research Institute leads AI and stem cell tech
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Katie Blue-Pugh was born with a major heart defect, a single ventricle, which was discovered when she was just a few hours old, causing panic for her parents and hospital staff in California. She was rushed to the University of California, San Francisco for life-saving surgery.

Despite undergoing multiple invasive procedures by the age of 9, Katie still struggled with her heart condition, unable to run across a playground without stopping due to low oxygen saturation and blue lips and nails. She eventually underwent a Fontan procedure to improve her quality of life.

Heart defects are common, affecting around one in every 100 live births in the US, according to the Centers for Disease Control and Prevention. Katie Blue-Pugh now lives in Durham, North Carolina, and while she leads a mostly normal life, she may still require a heart transplant in the future.

New research led by the Murdoch Children’s Research Institute (MCRI) in Australia, in collaboration with the Gladstone Institutes in San Francisco, aims to develop cutting-edge technologies to treat childhood heart disease more effectively. The initiative, known as “Decoding Broken Hearts,” focuses on personalized treatments to prevent the need for heart transplants.

Using stem cell technologies and advanced AI capabilities, the research aims to understand human disease biology and predict individual patient responses to therapies. This approach has the potential to treat various forms of heart disease, not just in children but also in adults.

The ultimate goal of the research is to eliminate heart defects before they even develop, by editing genes early on and preventing diseases from occurring in the first place. MCRI Global Ambassador, Sarah Murdoch, is passionate about eradicating the need for heart transplants in children, carrying on a legacy started by Dame Elisabeth Murdoch and Professor David Danks in 1986.

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Since its inception, MCRI has evolved from a genetics research institute to a leading global player in children’s health.

Today, MCRI is recognized as one of the top three child health research institutes worldwide for the outstanding quality and impact of its work.

An inspiring example of the advancements in heart research achieved by MCRI and Gladstone Institutes is evident in the story of Ebony and Kyle Mallison.

(L-R) Elijah, Ebony, Kyle, and Amelia Mallison at their home in Melbourne, Australia. Courtesy of Ebony Mallinson
Australian siblings Elijah and Amelia Mallinson both diagnosed with Cardiomyopathy. Courtesy of Ebony Mallinson

Amelia, their daughter, experienced heart failure at the age of 2 and was diagnosed with LVNC cardiomyopathy after waking up with severe swelling on Mother’s Day 2015.

“She spent a week in the ICU and another week on the cardiac ward before coming home,” shared Ebony, a 31-year-old receptionist from Melbourne, Australia.

Ebony Mallinson hopeful for research advancements to benefit her son Elijah. Courtesy of Ebony Mallinson

Later that year, Amelia underwent a life-saving heart transplant at just 3 years old, but ongoing research through the Decoding Broken Hearts initiative aims to provide alternative treatments for Elijah, who shares the same heart condition.

“Eli is stable for now, but we are optimistic that the research being conducted by MCRI will be instrumental in any future treatment he may require,” Ebony expressed.

Sarah Murdoch witnessed the challenges faced by children with heart disease and their families firsthand.

She recounted a visit to an 18-month-old toddler connected to a machine that pumped her blood, highlighting the urgency of finding solutions for these young patients.

Gladstone Institutes collaborating with MCRI on heart defect treatments. Gladstone Institute

One of MCRI’s significant achievements is the development of a vaccine to combat rotavirus, which was responsible for a significant number of deaths in developing countries in the past.

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The vaccine, recommended by WHO and introduced in 114 countries, has proven to be up to 90% effective in preventing severe rotavirus cases.

Ebony attested to the impact of MCRI’s research on her family, instilling hope and confidence in the future.

“Knowing that there are dedicated individuals working on solutions for my children and others nationwide is incredibly reassuring,” she remarked.

TAGGED:cellchildrensInstituteLeadsMurdochResearchSTEMTech
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