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American Focus > Blog > Tech and Science > New Treatment May Cure Severe Type 1 Diabetes, Study Finds : ScienceAlert
Tech and Science

New Treatment May Cure Severe Type 1 Diabetes, Study Finds : ScienceAlert

Last updated: June 23, 2025 5:05 am
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New Treatment May Cure Severe Type 1 Diabetes, Study Finds : ScienceAlert
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A groundbreaking stem cell treatment has shown promising results in improving the condition of volunteers with severe type 1 diabetes, with most participants able to discontinue insulin therapy altogether. This innovative therapy, developed by Boston-based Vertex Pharmaceuticals, offers hope for the 8.4 million individuals worldwide living with type 1 diabetes, an autoimmune disease that targets insulin-producing cells.

Type 1 diabetes patients rely on insulin therapy to regulate their blood sugar levels, as any imbalance can have serious consequences on their health. The new treatment, which involves infusions of stem cells derived from islet cells responsible for insulin production, has demonstrated the potential to restore the body’s insulin production.

In a phase 1/phase 2 clinical trial, 12 patients received islet cells derived from human stem cells in a treatment called zimislecel. These patients also underwent immunosuppressive therapy to support the integration of the new islet cells. The results showed that the infused islet cells were functional and self-regulated insulin production at safe levels, reducing the need for costly insulin doses.

While the treatment showed promising results, there were mild to moderate side effects associated with the immunosuppressive therapy, such as decreased kidney function and a drop in immune cells. Unfortunately, two participants passed away during the trial, one due to a surgery-related infection and the other from complications unrelated to the treatment.

Despite these challenges, the clinical trials have progressed to phase 3, as no serious adverse events were directly attributed to the islet cell therapy. The researchers involved in the study, led by University of Toronto surgeon Trevor Reichman, are optimistic about the potential of this treatment in effectively managing type 1 diabetes.

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The findings of this study, published in NEJM, highlight the possibility of using pluripotent stem cells to produce functional pancreatic islet cells for treating type 1 diabetes. With further research and development, this stem cell therapy could offer a new and promising approach to managing this chronic condition.

Overall, the results of this study provide hope for individuals living with type 1 diabetes, offering a potential alternative to traditional insulin therapy. As the research progresses, this innovative treatment may pave the way for more effective and personalized care for those affected by this challenging disease.

TAGGED:CureDiabetesfindsScienceAlertsevereStudyTreatmentType
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