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American Focus > Blog > Tech and Science > Regular Laxative Use May Raise Risks of Dementia And Depression : ScienceAlert
Tech and Science

Regular Laxative Use May Raise Risks of Dementia And Depression : ScienceAlert

Last updated: February 4, 2026 5:00 am
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Regular Laxative Use May Raise Risks of Dementia And Depression : ScienceAlert
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Laxatives are a common over-the-counter remedy for constipation, but are they safe for long-term use? While laxatives can be effective in getting things moving, it’s important to be cautious about using them regularly without medical guidance.

Types of Laxatives
There are five main types of oral laxatives available on the market:
1. Bulk-forming laxatives, such as Metamucil and Benefiber, which absorb water to form a soft, bulky stool and promote normal bowel muscle contractions.
2. Osmotic laxatives, like Osmolax and Movicol, which draw water into the colon to facilitate easier stool passage.
3. Stool softeners, such as Coloxyl, which help soften hard stool for easier elimination.
4. Stimulant laxatives, including Dulcolax and Senna, which stimulate bowel muscle contractions.
5. Lubricant laxatives, like Parachoc, which coat the bowel for smoother stool passage.

Starting a Laxative
Before turning to laxatives, it’s essential to first try dietary and lifestyle changes like increasing fiber intake, drinking more water, and engaging in physical activity. If constipation persists, consider starting with gentler options like bulk-forming laxatives or stool softeners. It’s always advisable to consult a doctor before starting any laxative regimen, especially if there are other concerning symptoms like rectal bleeding.

Do Laxatives Cause a ‘Lazy Colon’?
There have been concerns in the past about the potential for long-term laxative use to result in a condition known as a “cathartic colon,” where the colon loses muscle function. However, recent reviews have found no conclusive evidence linking chronic stimulant laxative use to gut damage. It’s still important to use laxatives cautiously and under medical supervision.

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Gut Symptoms and Electrolytes
Laxative abuse, particularly for weight loss purposes, can lead to electrolyte imbalances and serious complications like muscle weakness, heart issues, and changes in heart rhythm. While the risk of these complications is low when taking laxatives as directed, abuse can have severe consequences on the body’s electrolyte balance.

Depression, Dementia, and Mental Health
Studies have shown a correlation between regular laxative use and a higher risk of developing depression and dementia. Chronic laxative abuse may affect the microbiome-gut-brain axis, potentially contributing to mental health conditions. It’s crucial for individuals abusing laxatives to undergo a comprehensive mental health assessment and receive appropriate support.

Safe Use of Laxatives
While laxatives can be beneficial for treating constipation, they should be used cautiously and under medical guidance. It’s always best to consult a healthcare provider before starting a laxative regimen, especially if you have underlying medical conditions or are taking other medications. Prioritizing dietary and lifestyle changes can also help improve bowel function without the need for long-term laxative use.

TAGGED:dementiaDepressionLaxativeraiseregularRisksScienceAlert
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