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American Focus > Blog > Entertainment > Rosie O’Donnell Reveals Mounjaro Dosage, Talks Side Effects
Entertainment

Rosie O’Donnell Reveals Mounjaro Dosage, Talks Side Effects

Last updated: July 28, 2026 6:55 am
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Rosie O’Donnell Reveals Mounjaro Dosage, Talks Side Effects
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Rosie O’Donnell has opened up about her experience with weight loss aided by the drug Mounjaro.

The 64-year-old former talk show host shared on the July 27 episode of the “Bleep! With Ana Navarro” podcast that she has shed around 60 pounds over three years while using the medication.

During her conversation with Ana Navarro, O’Donnell detailed her dosage regimen, stating, “I started with the lowest dose, 2.5 milligrams, for a year. Then I moved to 5 milligrams for another year, and now I’m concluding a year on 7.5 milligrams.”

She mentioned her intention to increase the dosage “one more time,” after which she does not plan any further increments.

Related: Rosie O’Donnell and More Stars Who’ve Used Mounjaro for Weight Loss

In May 2025, Rosie O’Donnell delighted her fans with a favorable update on her weight loss journey, attributing her progress to the medication Mounjaro. This injectable, also known as tirzepatide, is akin to Ozempic and Wegovy, primarily used to manage diabetes but also effective for weight loss.

The comedian emphasized her cautious approach to gradually increasing her Mounjaro dosage to optimize her well-being.

“I took it slow because rapid weight loss in the past was overwhelming due to reactions from others,” she explained. “I prefer this gradual approach. I feel good, and I haven’t experienced any side effects.”

Navarro, 54, expressed surprise at O’Donnell’s lack of side effects, asking, “You’ve never had to rush to the bathroom?”

“Never,” O’Donnell replied. “I spent a year on 2.5 milligrams. Despite my doctor urging me to increase, I felt comfortable at that level.”

GettyImages-2239463962-rosie-odonnel

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Related: Rosie O’Donnell Reveals She Had a Facelift After Being ‘Morally’ Against It

Earlier this year, Rosie O’Donnell underwent a facelift, a procedure she previously opposed. In a poem titled “Decisions” shared on May 25, she expressed her former strong moral stance against such surgeries.

Rosie O’Donnell recently discussed how Mounjaro, prescribed for type 2 diabetes and weight loss, has significantly improved her life after years of struggling with weight issues following her mother’s death in 1973.


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She shared with People that after her mother’s passing, she and her siblings gained weight. “My father gave us a hundred-dollar bill for grocery shopping at Foodtown. As 11-year-olds shopping for five, we chose unhealthy items like Entenmann’s and Cap’n Crunch, often putting back nutritious foods like chicken and hamburger when we neared the budget,” she explained. “Everyone was gaining weight, overshadowed by grief and trauma.”

O’Donnell credits Mounjaro with transforming her life, stating, “I’ve steadily lost one to two pounds a month over three years. I wish I could do Mounjaro commercials for free if it would lower the cost. Witnessing people struggle with obesity, I empathize with the shame and humiliation they endure.”

She describes Mounjaro as a “miracle drug,” marveling at its ability to quiet her obsession with food. “I’ve battled weight issues my entire life. While some are hesitant to discuss it, I believe in sharing how Mounjaro has helped me, as I dislike keeping secrets.”

TAGGED:DosageeffectsMounjaroODonnellRevealsRosiesideTalks
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