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American Focus > Blog > Tech and Science > Vagus nerve stimulation receives US approval to treat arthritis
Tech and Science

Vagus nerve stimulation receives US approval to treat arthritis

Last updated: August 1, 2025 1:15 am
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Vagus nerve stimulation receives US approval to treat arthritis
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New Scientist. Science news and long reads from expert journalists, covering developments in science, technology, health and the environment on the website and the magazine.

Targeting the vagus nerve has shown medical promise for a range of health conditions

Science Photo Library/Alamy

The recent approval by the US Food and Drug Administration (FDA) of a vagus nerve stimulator for rheumatoid arthritis marks a significant milestone in the treatment of autoimmune conditions. This groundbreaking device, the first of its kind to be cleared for an autoimmune disorder, has the potential to revolutionize the management of such conditions and pave the way for broader applications.

Implanted surgically along the vagus nerve, which serves as a crucial link between the brain and vital organs, this pill-sized device delivers electrical pulses over a period of up to ten years. These pulses stimulate the nerve and help reduce inflammation, a key factor in conditions like rheumatoid arthritis, where the body’s immune system mistakenly attacks its own tissues, causing pain, swelling, and potential organ damage. Current treatments for rheumatoid arthritis typically involve potent anti-inflammatory drugs that suppress the immune system, leading to increased risks of infections and cancer. Dissatisfaction with these treatments, as evidenced by nearly three-quarters of patients, often results in non-compliance due to severe side effects.

In a clinical trial involving 242 individuals with moderate to severe rheumatoid arthritis, those who received vagus nerve stimulation for 12 weeks experienced a significant reduction in symptoms compared to those who did not receive the treatment. Approximately 35% of the treatment group saw at least a 20% improvement in symptoms, highlighting the efficacy of this innovative approach. Moreover, the incidence of serious side effects was minimal, with less than 2% of participants experiencing any adverse reactions, and none developing serious infections.

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Dr. Kevin Tracey, a pioneer in the development of this device at the Feinstein Institutes for Medical Research, emphasizes the potential benefits of using a safe, non-invasive technology as opposed to traditional medications with limited effectiveness and severe side effects. This approval sets the stage for the future use of vagus nerve stimulation in addressing a wide range of inflammation-related conditions, such as heart failure, diabetes, and neurodegenerative diseases like Parkinson’s. Ongoing clinical trials by SetPoint Medical, the company behind the device, are exploring its application in multiple sclerosis and inflammatory bowel disease, further underscoring its versatility and promise in the field of medical innovation.

TAGGED:ApprovalarthritisNERVEreceivesstimulationtreatVagus
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