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American Focus > Blog > Tech and Science > Psychedelic causes similar brain state in spiritual lama as meditation
Tech and Science

Psychedelic causes similar brain state in spiritual lama as meditation

Last updated: February 4, 2026 4:41 pm
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Psychedelic causes similar brain state in spiritual lama as meditation
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A seasoned meditator has dedicated 15 years to mastering the art of quieting his sense of self. Brain scans now suggest that he has achieved a similar altered state using a potent psychedelic substance.

Christopher Timmermann, a researcher at University College London, explains that there is a significant overlap in brain activity between a low dose of the psychedelic 5-MeO-DMT and a non-dual meditation state. This style of meditation blurs the lines between the self and the external world.

The field of psychedelic research is expanding rapidly, with scientists delving into how these substances can enhance our understanding of consciousness and mental well-being. Of particular interest is 5-MeO-DMT, a compound commonly found in the North American toad, which has been shown to disrupt mental processing rapidly without inducing vivid visuals like other psychedelics.

Timmermann and his team conducted a study comparing the effects of 5-MeO-DMT-induced psychedelic states with advanced meditation. They collaborated with a lama from the Karma Kagyu school of Tibetan Buddhism, a master with over 54,000 hours of meditation experience.

During three separate lab visits, the lama engaged in uninterrupted meditation for 30 to 60 minutes before receiving either a placebo or a low or high dose of 5-MeO-DMT. Brain activity was monitored during each state, and the lama provided feedback on his thoughts and sense of self afterward.

The results showed that the low dose of 5-MeO-DMT (5 milligrams) produced brain activity patterns similar to those observed during meditation. Both practices increased alpha power, associated with relaxed wakefulness and internal focus, while reducing gamma activity linked to active cognitive engagement.

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The lama reported a sense of equanimity during both the low-dose 5-MeO-DMT experience and meditation, with thoughts arising and dissipating quickly. However, meditation provided a stronger sense of interconnectedness and mental clarity.

In contrast, the high dose of 5-MeO-DMT (12 milligrams) led to increased gamma activity, disconnecting the lama from his surroundings and inducing a profound sense of ego dissolution. The experience was marked by a loss of perception of the body and external environment.

The study’s findings shed light on the neural pathways associated with “ego dissolution” and “contentless awareness.” However, subjective experiences cannot be fully explained by changes in brain activity alone, according to Matthew Sacchet of Harvard Medical School.

While the study was limited to a single experienced meditator, further research could explore the potential benefits of 5-MeO-DMT for a broader population. Timmermann is investigating whether the substance can accelerate the progress of novice meditators, although he emphasizes the importance of safe and legal use.

Sacchet suggests that for those interested in the mental health benefits of 5-MeO-DMT, meditation offers a safer alternative. By pursuing meditation, individuals may achieve states that partially overlap with psychedelic effects without the risks associated with substance use.

In conclusion, the study highlights the potential synergy between psychedelics and meditation in altering consciousness and enhancing well-being. Further research may uncover novel insights into the therapeutic applications of these practices for mental health and personal growth. The world of technology is constantly evolving, with new innovations and advancements being made every day. One of the most exciting and cutting-edge developments in recent years is the rise of artificial intelligence (AI) technology. AI has the potential to revolutionize industries ranging from healthcare to finance to transportation, and its impact is already being felt in many areas of our lives.

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AI refers to the simulation of human intelligence in machines that are programmed to think and learn like humans. This technology is capable of performing tasks that typically require human intelligence, such as visual perception, speech recognition, decision-making, and language translation. AI-powered systems can analyze vast amounts of data at high speeds, making them invaluable tools for businesses looking to gain insights and make more informed decisions.

One of the key benefits of AI technology is its ability to automate routine tasks, freeing up human workers to focus on more complex and strategic activities. For example, in the healthcare industry, AI-powered diagnostic tools can analyze medical images and patient data to help doctors make more accurate diagnoses and treatment recommendations. In the financial sector, AI algorithms can analyze market trends and make investment decisions in real-time, leading to better returns for investors.

In addition to improving efficiency and productivity, AI technology also has the potential to enhance customer experiences. Chatbots powered by AI can provide instant support and assistance to customers, while personalized recommendations based on machine learning algorithms can help businesses tailor their products and services to individual preferences.

Despite its many benefits, AI technology also raises concerns about job displacement and ethical considerations. As AI becomes more advanced, there is a fear that it could replace human workers in certain industries, leading to unemployment and economic disruption. Additionally, the use of AI in decision-making processes raises questions about accountability and transparency, as algorithms may not always be able to explain their reasoning.

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Overall, the rise of AI technology represents a significant milestone in the field of technology and has the potential to transform the way we live and work. As the technology continues to advance, it will be important for businesses and policymakers to address the challenges and opportunities that AI presents in order to ensure that its benefits are maximized and its risks are mitigated.

TAGGED:brainlamaMeditationpsychedelicsimilarSpiritualState
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