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American Focus > Blog > Sports > Cleveland Cavaliers vs New Orleans Pelicans Preview: Starting Lineups Tonight, Betting Tips and Game Prediction (Mar. 21)
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Cleveland Cavaliers vs New Orleans Pelicans Preview: Starting Lineups Tonight, Betting Tips and Game Prediction (Mar. 21)

Last updated: March 21, 2026 12:10 am
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Cleveland Cavaliers vs New Orleans Pelicans Preview: Starting Lineups Tonight, Betting Tips and Game Prediction (Mar. 21)
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On Saturday, the Cleveland Cavaliers and New Orleans Pelicans will face off in a regular-season game at the Smoothie King Center, with the game set to start at 7 p.m. ET. This will be the second and last game between the two teams this season, with the Cavaliers having won the first encounter 141-118.

The Cavaliers are on a two-game winning streak and currently hold fourth place in the Eastern Conference with a 43-27 record. In contrast, the Pelicans are on a three-game winning streak but sit in 11th place in the Western Conference with a 25-46 record.

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Cleveland Cavaliers vs. New Orleans Pelicans Preview, Starting Lineups Tonight, Betting Tips and Game Prediction

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Cleveland Cavaliers vs. New Orleans Pelicans Betting Tips and Odds

Moneyline: Cavaliers (-198), Pelicans (+166)

Spread: Cavaliers -5.5 (+100), Pelicans +5.5 (-120)

Total over/under o/u: Cavaliers o236.5 (-111), Pelicans u236.5 (-111)

Editor’s note: Odds might change closer to tipoff.

Betting Tips

  • James Harden is expected to record over 7.5 assists.
  • Zion Williamson is expected to record under 5.5 rebounds.
  • Trey Murphy III is expected to make over 3.5 3-pointers.

Cleveland Cavaliers vs. New Orleans Pelicans Preview

The Cavaliers are entering this game following a 115-110 victory over the Chicago Bulls on Thursday. In that game, James Harden put on a stellar performance, contributing 36 points, seven rebounds, nine assists, and two steals, with seven successful 3-pointers.

Evan Mobley also impressed with a double-double, scoring 26 points and grabbing 14 rebounds while shooting 12 of 19 from the field. Donovan Mitchell did not play in the previous game and is listed as questionable due to a left eye contusion.

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Meanwhile, the Pelicans beat the LA Clippers 105-99 in their last game. Trey Murphy III was on target from beyond the arc, scoring 27 points with five 3-pointers. Yves Missi added a double-double with 11 points and 11 rebounds, and Saddiq Bey contributed 20 points, six rebounds, and six assists.

Dejounte Murray was absent in the last game but is set to return against the Cavaliers, which will move Missi back to the bench.

Cleveland Cavaliers vs. New Orleans Pelicans Starting Lineups Tonight

Cleveland Cavaliers starting lineup

PG: James Harden, SG: Sam Merrill, SF: Jaylon Tyson, PF: Dean Wade, C: Evan Mobley.

New Orleans Pelicans starting lineup

PG: Dejounte Murray, SG: Trey Murphy III, SF: Saddiq Bey, PF: Zion Williamson, C: Herbert Jones.

Cleveland Cavaliers vs. New Orleans Pelicans Prediction

The Cavaliers’ robust defense gives them a slight advantage going into this matchup. Despite the Pelicans playing at home, Cleveland is expected to disrupt New Orleans’ plans at the Smoothie King Center on Saturday.

Final score prediction: Cavaliers win 120-114.

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Edited by Atishay Jain

Contents
Cleveland Cavaliers vs. New Orleans Pelicans Preview, Starting Lineups Tonight, Betting Tips and Game PredictionCleveland Cavaliers vs. New Orleans Pelicans PreviewCleveland Cavaliers vs. New Orleans Pelicans Starting Lineups TonightCleveland Cavaliers vs. New Orleans Pelicans Prediction
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