Tennis legend Serena Williams has been making headlines for both her incredible career and her recent transformation since retiring from professional tennis three years ago. The 23-time Grand Slam champion has reportedly lost 31 pounds, largely attributed to the weight-loss medication Zepbound, as RadarOnline.com has unveiled.
Similar to other GLP-1 drugs like Ozempic, Zepbound aids in appetite suppression and enhances sensations of fullness, helping users achieve their weight-loss goals.
The newly toned icon took to social media to confirm her use of the medication after fans speculated about her body transformation following recent gym selfies.
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Serena’s Admission
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Reddit cofounder Alexis Ohanian, her husband, has invested in Ro, the company providing her access to Zepbound.
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The 43-year-old mother of two turned to Zepbound via Ro, where she also serves as a spokesperson. Williams has voiced her long-term struggle with weight loss, even with a rigorous fitness regimen and a healthy diet.
While effective for many, this medication can also lead to side effects, including nausea, diarrhea, fatigue, and in some cases more severe risks like pancreatitis and kidney complications.
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Mixed Reactions to Serena’s Transformation
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Fans on Instagram expressed concerns about Williams’ appearance, noting what some referred to as an ‘Ozempic face.’
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The term “Ozempic face”, characterized by facial gauntness, sunken cheeks, and increased wrinkles, has been noted by critics. Fans reacted mixedly to Williams’ new look — while some expressed concern, others defended her by stating she looks great regardless of her weight loss.
“Is Serena okay? This has been a shocking weight loss,” one fan remarked on Instagram, while another stated, “Not feeling the Ozempic Serena version.”

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Many fans commended Serena for her confidence, noting that she embraces her new body regardless of critics.
While some fans focus on her looks, many have rallied to support her through these changes. “Serena you look great. With the weight or not, you are a world-class athlete,” praised one user in response to her posts. Another added, “The slayage has reached new heights!”
In any case, Williams is adopting a confident attitude about her body transformation and stated, “I feel sexier, I feel more confident, and I don’t really care what people are saying about my body anymore.”
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