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American Focus > Blog > Lifestyle > The New STIs: Mycoplasma, Ureaplasma, and the Things No One Tells You
Lifestyle

The New STIs: Mycoplasma, Ureaplasma, and the Things No One Tells You

Last updated: September 24, 2025 3:39 pm
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The New STIs: Mycoplasma, Ureaplasma, and the Things No One Tells You
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Contents
The Silent Colonizers: Understanding Ureaplasma and Mycoplasma InfectionsWhat are Ureaplasma and Mycoplasma?Are They Sexually Transmitted?The Testing DilemmaConservative Approaches to TreatmentCommon Misdiagnoses and the Importance of Individual CareWomen in Diagnostic Limbo



The Silent Colonizers: Understanding Ureaplasma and Mycoplasma Infections

In an enlightening conversation, I connected with two esteemed professionals in the field of urology and pelvic health: Dr. Angelish Kumar, a board-certified urologist, and Sonia Bahlani, a pelvic pain specialist. Their previous appearances on my podcast, Going Mental, set the stage for a candid discussion about these often-overlooked bacteria.

What are Ureaplasma and Mycoplasma?

Dr. Kumar elaborated on these tiny bacterial inhabitants, stating, “Ureaplasma and Mycoplasma are microorganisms that reside in the genitourinary tracts of both men and women. In many individuals, they cohabit peacefully with other microbes without causing any issues. However, for some, these bacteria can become triggers for discomfort and pain.” This variability in response underscores the complexity of these infections.

Are They Sexually Transmitted?

When I inquired about the classification of these bacteria as sexually transmitted infections, Dr. Kumar confirmed, “Yes, they can be transmitted through sexual activity. Should treatment be warranted, it's essential for sexual partners to also receive treatment.”

The Testing Dilemma

This leads to a critical question: If Ureaplasma and Mycoplasma can be sexually transmitted and lead to potential health issues, why aren’t they routinely tested for by ob-gyns, urologists, and other healthcare providers?

Dr. Kumar provided clarity: “These bacteria can frequently exist without any symptoms or problems in many individuals. Therefore, testing is typically indicated for women presenting with symptoms such as abnormal vaginal discharge or pelvic pain.”

Conservative Approaches to Treatment

Even with presenting symptoms, the approach to treatment isn’t straightforward. Bahlani advocated for a more cautious stance: “If there are no symptoms, I generally do not recommend testing or treating. Aggressive treatment of bacterial colonization can lead to unnecessary antibiotic prescriptions, increased resistance, and additional anxiety for patients. Testing is judicious only when persistent pelvic or urinary symptoms arise without an alternative explanation.”

Common Misdiagnoses and the Importance of Individual Care

Dr. Kumar frequently encounters cases where women are treated for Ureaplasma based on inconclusive lab results, only to discover different underlying issues. She noted, “For instance, a patient may receive doxycycline for Ureaplasma but continue to experience symptoms, ultimately revealing that a persistent E. coli UTI was the actual cause.”

Women in Diagnostic Limbo

A broader concern is the diagnostic uncertainty many women face, particularly when symptoms diverge from textbook presentations. Dr. Kumar emphasized, “The manifestation of infections can differ significantly among individuals, influenced by factors such as genetics, immune system function, microbiome diversity, diet, lifestyle, and environmental exposures. When treating patients, we must remember we are addressing unique individuals, not merely lab findings. This highlights the intersection of art and science in medicine.”

Ultimately, understanding Ureaplasma and Mycoplasma infections requires a nuanced approach that considers the individual’s specific circumstances, which can lead to more effective and empathetic care.

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