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Tech and Science

Upheavals to the oral microbiome in pregnancy may be behind tooth loss

Last updated: November 28, 2025 8:20 pm
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Upheavals to the oral microbiome in pregnancy may be behind tooth loss
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Pregnancy and Oral Health: The Impact on the Oral Microbiome

“Pregnancy is known to be linked to a heightened risk of dental issues, but we aren’t entirely sure why. Now, researchers have found that the oral microbiome changes while a woman is expecting, becoming less diverse and potentially more prone to causing inflammation.”

The hormonal changes that occur during pregnancy are often blamed for the increased risk of conditions like gum disease and tooth decay. However, the idea that fetuses take calcium from their mother’s teeth is not supported by evidence. Instead, disruptions to the oral microbiome, which is composed of more than 700 species of bacteria, can lead to dental problems. To understand how pregnancy affects the oral microbiome, researchers collected saliva samples from 346 women at different stages of pregnancy.

The study revealed that the diversity of species in the saliva samples decreased as early as the transition between the first and second trimester, continuing to decline throughout the rest of the pregnancy. Key changes included a reduction in beneficial bacteria like Akkermansia muciniphila and an increase in bacteria associated with inflammation. These changes, although small overall, were accelerated during pregnancy, mirroring the slow evolution that typically occurs over many years in just nine months.

Various factors such as hormonal fluctuations, changes in diet, inflammation, and other health conditions can contribute to these alterations in the oral microbiome during pregnancy. The study also found distinct effects among women who followed a gluten-free diet, took antibiotics, experienced stress, or were current or ex-smokers. These changes were consistent in a separate experiment involving pregnant women from Russia.

While pregnancy is known to increase the risk of dental issues, researchers are still exploring the role of the oral microbiome in these conditions. Changes in the oral microbiome, along with increased acidity in saliva during pregnancy, may contribute to dental problems. Understanding the optimal composition of the oral microbiome during pregnancy could help in monitoring the progression of pregnancy and identifying potential complications.

Moreover, disruptions to the oral microbiome have been linked to pregnancy complications, highlighting the importance of maintaining good oral hygiene and a diverse, nutrient-rich diet. By understanding how the oral microbiome influences the immune system, we may be able to improve the health outcomes of both pregnant women and their fetuses. Ultimately, maintaining a healthy oral microbiome could have long-lasting implications for the overall health of both parents and children.

TAGGED:LossmicrobiomeOralpregnancyToothUpheavals
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